Mechanism of the Inhibitory Effect of Adenine Nucleotides on Porphyrin Synthesis by Rhodopseudomonas spheroides

EXCESS biosynthesis of porphyrins is strongly decreased by some adenine nucleosides and nucleotides (inosine, 5′ AMP, 5′ ADP, 5′ ATP) in vivo as well as in vitro 1–3 . Experiments with Rhodopseudomonas spheroides have shown that ATP is the most active of these adenine derivatives, determining a more...

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Bibliographic Details
Published in:Nature (London) 1965-08, Vol.207 (4997), p.640-641
Main Authors: GAJDOS, A, GAJDOS-TÖRÖK, M
Format: Article
Language:English
Subjects:
Humanities and Social Sciences
letter
multidisciplinary
Science
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Summary:EXCESS biosynthesis of porphyrins is strongly decreased by some adenine nucleosides and nucleotides (inosine, 5′ AMP, 5′ ADP, 5′ ATP) in vivo as well as in vitro 1–3 . Experiments with Rhodopseudomonas spheroides have shown that ATP is the most active of these adenine derivatives, determining a more than 90 per cent inhibition 2,3 in a concentration of 3 m.moles/l. of medium. On the other hand, it was established that this effect is confined to the step of ALA formation 2,3 .
ISSN:0028-0836
1476-4687
DOI:10.1038/207640b0