Gonadotrophin-inhibiting Action of Certain Carbohydrates

A GONADOTROPHIN-INHIBITING substance has been reported to occur in the urine of children 1 and adults 2,3 and in certain samples of human serum 4 . It inhibits the action of human chorionic gonadotrophins (HCG) and luteinizing hormone (LH), but is ineffective against the action of follicle-stimulati...

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Bibliographic Details
Published in:Nature (London) 1966-08, Vol.211 (5052), p.975-976
Main Authors: AMIR, S. M, BARKER, S. A, BUTT, W. R, CROOKE, A. C
Format: Article
Language:English
Subjects:
Humanities and Social Sciences
letter
multidisciplinary
Science
Science (multidisciplinary)
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Summary:A GONADOTROPHIN-INHIBITING substance has been reported to occur in the urine of children 1 and adults 2,3 and in certain samples of human serum 4 . It inhibits the action of human chorionic gonadotrophins (HCG) and luteinizing hormone (LH), but is ineffective against the action of follicle-stimulating hormone (FSH). This communication reports the observation of certain similar effects using N -acetyl- D -neuraminic acid ( D -NANA)—a constituent of both HCG and FSH, and using the related compound N -acetyl- D -mannosamine ( D -NAM).
ISSN:0028-0836
1476-4687
DOI:10.1038/211975a0