Administration of N -Acetyl- D -mannosamine to Mammals

N -ACETYL- D -mannosamine (NAM) is biochemically related to N -acetyl- D -neuraminic acid (NANA), a constituent of both human follicle stimulating hormone and human chorionic gonadotrophin (HCG). The compound itself is devoid of biological activity, but when mixed with HCG it reduces the activity of...

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Bibliographic Details
Published in:Nature (London) 1966-08, Vol.211 (5052), p.976-977
Main Authors: AMIR, S. M, BARKER, S. A, BUTT, W. R, CROOKE, A. C, DAVIES, A. G
Format: Article
Language:English
Subjects:
Animals
Digestive System - analysis
Female
Hexosamines - blood
Hexosamines - metabolism
Humanities and Social Sciences
Humans
letter
Lung - analysis
multidisciplinary
Myocardium - analysis
Ovary - analysis
Pituitary Gland - analysis
Rats
Science
Science (multidisciplinary)
Sheep
Skin - analysis
Thyroid Gland - analysis
Uterus - analysis
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Summary:N -ACETYL- D -mannosamine (NAM) is biochemically related to N -acetyl- D -neuraminic acid (NANA), a constituent of both human follicle stimulating hormone and human chorionic gonadotrophin (HCG). The compound itself is devoid of biological activity, but when mixed with HCG it reduces the activity of this hormone in both the uterine weight and ovulation assays 1 . We therefore considered it to be of interest to study the fate of NAM after the administration of it to mammals.
ISSN:0028-0836
1476-4687
DOI:10.1038/211976a0