Antitumour Activity of N -Hydroxyurethane

N -HYDROXYURETHANE is known to be a carcinogen and to induce certain chromosomal aberrations 1,2 . It contains the hydroxamic acid group, a moiety apparently essential for the antitumour activity of hydroxyurea and its congeners 3,4 . For this reason, it was considered of interest to determine wheth...

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Bibliographic Details
Published in:Nature (London) 1966-08, Vol.211 (5052), p.984-985
Main Authors: HAHN, MARY ANNE, BOTKIN, CONSTANCE C, ADAMSON, RICHARD H
Format: Article
Language:English
Subjects:
Animals
Humanities and Social Sciences
letter
Leukemia L1210
Leukemia, Experimental
Mast Cells
Mice
multidisciplinary
Neoplasms, Experimental
Plasmacytoma
Science
Science (multidisciplinary)
Urethane - pharmacology
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Summary:N -HYDROXYURETHANE is known to be a carcinogen and to induce certain chromosomal aberrations 1,2 . It contains the hydroxamic acid group, a moiety apparently essential for the antitumour activity of hydroxyurea and its congeners 3,4 . For this reason, it was considered of interest to determine whether N -hydroxyurethane was active against various transplantable mouse tumours.
ISSN:0028-0836
1476-4687
DOI:10.1038/211984a0