Actions of Thrombin and Other Coagulant and Proteolytic Enzymes on Blood Platelets

The action of thrombin on fibrinogen is not responsible for its effect on platelets. Thrombin does, however, have an enzyme effect on a platelet constituent: this requires an unsubstituted serine hydroxyl group and a group susceptible to acetylation.

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Bibliographic Details
Published in:Nature (London) 1967-12, Vol.216 (5118), p.857-858
Main Authors: DAVEY, M. G, LÜSCHER, E. F
Format: Article
Language:English
Subjects:
Amino Acids - metabolism
Blood Coagulation Factors - pharmacology
Blood Platelets - drug effects
Electrophoresis
Fibrinogen - metabolism
Humanities and Social Sciences
Humans
multidisciplinary
Papain - pharmacology
Peptide Hydrolases - pharmacology
Science
Science (multidisciplinary)
Thrombin - pharmacology
Trypsin - pharmacology
Venoms - pharmacology
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Description
Summary:The action of thrombin on fibrinogen is not responsible for its effect on platelets. Thrombin does, however, have an enzyme effect on a platelet constituent: this requires an unsubstituted serine hydroxyl group and a group susceptible to acetylation.
ISSN:0028-0836
1476-4687
DOI:10.1038/216857a0