Normal Immune Responses of Bursaless Chickens to a Secondary Antigenic Stimulus

Hormonal bursectomy—inhibition of the development of the bursa by testosterone—has been more effective than surgical bursectomy coupled with irradiation in depressing the primary response to soluble antigens. None of the treated birds was agammaglobulinaemic, and all formed some antibody.

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Bibliographic Details
Published in:Nature (London) 1968-01, Vol.217 (5125), p.231-235
Main Authors: ROSE, M. ELAINE, ORLANS, EVA
Format: Article
Language:English
Subjects:
Agammaglobulinemia
Agglutination Tests
Animals
Antibody Formation
Antigen-Antibody Reactions
Body Weight
Bursa of Fabricius - drug effects
Bursa of Fabricius - growth & development
Bursa of Fabricius - physiology
Cattle
Chickens - radiation effects
gamma-Globulins - metabolism
Humanities and Social Sciences
Immunodiffusion
Immunoelectrophoresis
Lymphocytes
multidisciplinary
Radiation Effects
Science
Serum Albumin, Bovine - pharmacology
Testosterone - pharmacology
Thymectomy
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Description
Summary:Hormonal bursectomy—inhibition of the development of the bursa by testosterone—has been more effective than surgical bursectomy coupled with irradiation in depressing the primary response to soluble antigens. None of the treated birds was agammaglobulinaemic, and all formed some antibody.
ISSN:0028-0836
1476-4687
DOI:10.1038/217231a0