Kinetic Study of the Production of Antibody-forming Cells from their Precursors

THERE is considerable evidence to indicate that, in the mouse, the immediate precursor of the antibody-forming cell is derived from an antigen-insensitive stem cell present in bone marrow 1–3 . Following immunization with sheep erythrocytes (SRBC), such precursor cells normally proliferate and diffe...

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Bibliographic Details
Published in:Nature (London) 1968-06, Vol.218 (5146), p.1079-1081
Main Authors: GREGORY, CONNIE J, LAJTHA, L. G
Format: Article
Language:English
Subjects:
Animals
Antibody Formation
Cell Differentiation
Cell Division
Humanities and Social Sciences
Kinetics
letter
Male
Mice
multidisciplinary
Radiation Effects
Science
Science (multidisciplinary)
Spleen - radiation effects
Spleen - transplantation
Thoracic Duct - immunology
Thymus Gland - growth & development
Transplantation, Homologous
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Summary:THERE is considerable evidence to indicate that, in the mouse, the immediate precursor of the antibody-forming cell is derived from an antigen-insensitive stem cell present in bone marrow 1–3 . Following immunization with sheep erythrocytes (SRBC), such precursor cells normally proliferate and differentiate giving rise to specific antibody-forming progeny 4–6 .
ISSN:0028-0836
1476-4687
DOI:10.1038/2181079a0