Isolation of Chlorpromazine Pigments in Man

OCULOCUTANEOUS pigmentation occurs in man during long-term chlorpromazine therapy 1,2 , diffuse purple pigmentation of the skin of the face, neck and dorsum of the hands being the most characteristic finding. The distribution and intensity of the skin pigmentation correlate with exposure to sunlight...

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Bibliographic Details
Published in:Nature (London) 1968-09, Vol.219 (5158), p.1054-1056
Main Author: VAN WOERT, MELVIN H
Format: Article
Language:English
Subjects:
Centrifugation
Chemical and Drug Induced Liver Injury
Chlorpromazine - adverse effects
Female
Humanities and Social Sciences
Humans
Infrared Rays
letter
Liver - analysis
Liver - drug effects
Liver - pathology
Middle Aged
multidisciplinary
Pigmentation Disorders - chemically induced
Pigments, Biological - analysis
Schizophrenia - drug therapy
Science
Science (multidisciplinary)
Spectrum Analysis
Ultraviolet Rays
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Summary:OCULOCUTANEOUS pigmentation occurs in man during long-term chlorpromazine therapy 1,2 , diffuse purple pigmentation of the skin of the face, neck and dorsum of the hands being the most characteristic finding. The distribution and intensity of the skin pigmentation correlate with exposure to sunlight. Corneal and lenticular opacities are frequently also present in these patients 1 .
ISSN:0028-0836
1476-4687
DOI:10.1038/2191054a0