Cylophosphamide Treatment of Gnotobiotic Mice congenitally infected with Lymphocytic Choriomeningitis Virus

MICE with congenital lymphocytic choriomeningitis (LCM) virus infection eventually manifest expanding lesions of the lymphoreticular system which results in glomerulonephritis 1 . The age-incidence and the intensity of the disease seem to vary among mouse strains, which possibly differ in host level...

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Bibliographic Details
Published in:Nature (London) 1969-11, Vol.224 (5220), p.707-709
Main Authors: SHARON, NEHAMA, POLLARD, MORRIS
Format: Article
Language:English
Subjects:
Humanities and Social Sciences
letter
multidisciplinary
Science
Science (multidisciplinary)
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Summary:MICE with congenital lymphocytic choriomeningitis (LCM) virus infection eventually manifest expanding lesions of the lymphoreticular system which results in glomerulonephritis 1 . The age-incidence and the intensity of the disease seem to vary among mouse strains, which possibly differ in host levels of viraemia, or antibody response, or both 2 . Germfree mice, congenitally infected with LCM virus (LCM mice), developed virus-related lesions which indicated hyperactivity of immunological mechanisms; and this was characterized by depletion of cortical thymocytes, swollen lymph nodes and spleens with very large germinal zones, infiltrations of many organs with lymphoid cells (including plasma cells), hypergammaglobulinaemia and degenerative kidney changes 3,4 .
ISSN:0028-0836
1476-4687
DOI:10.1038/224707a0