Effects on Smooth Muscle Preparations of Unidentified Vasoactive Peptides from Intestine and Lung

EXTRACTS of lung 1,2 and of small intestine 3 from the pig contain previously unidentified vasoactive peptides which, when given intravenously, increase peripheral blood flow and cause a systemic hypotension, both effects being long lasting. Although the peptide fractions from the lung and small int...

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Bibliographic Details
Published in:Nature (London) 1970-03, Vol.225 (5238), p.1144-1146
Main Authors: PIPER, PRISCILLA J, SAID, S. I, VANE, J. R
Format: Article
Language:English
Subjects:
Humanities and Social Sciences
letter
multidisciplinary
Science
Science (multidisciplinary)
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Summary:EXTRACTS of lung 1,2 and of small intestine 3 from the pig contain previously unidentified vasoactive peptides which, when given intravenously, increase peripheral blood flow and cause a systemic hypotension, both effects being long lasting. Although the peptide fractions from the lung and small intestine are extractable by similar techniques, the vascular responses they elicit are somewhat different. One peptide from the intestine induced a quicker and more pronounced vasodilatation than either the second peptide from intestine or that from lung 3 . These substances have not yet been completely purified, and so their activity may be due to a single compound or to several different ones. Because of the short supply of extracted peptides, investigation of their biological activity has been limited largely to their peripheral vasodilator effect.
ISSN:0028-0836
1476-4687
DOI:10.1038/2251144a0