New Model for Schistosome Granuloma Formation using a Soluble Egg Antigen and Bentonite Particles

INJECTION of purified Schistosoma mansoni eggs into mice results in granuloma formation 1 , and it has been shown that egg antigen is gradually released to phagocytes which accumulate around the eggs and engage in antigen sequestration and destruction in situ 2 . Schistosome granuloma formation as s...

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Bibliographic Details
Published in:Nature (London) 1971-01, Vol.229 (5281), p.199-200
Main Authors: LICHTENBERG, FRANZ VON, SMITH, THOMAS M, LUCIA, HELEN L, DOUGHTY, BARBARA L
Format: Article
Language:English
Subjects:
Humanities and Social Sciences
letter
multidisciplinary
Science
Science (multidisciplinary)
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Summary:INJECTION of purified Schistosoma mansoni eggs into mice results in granuloma formation 1 , and it has been shown that egg antigen is gradually released to phagocytes which accumulate around the eggs and engage in antigen sequestration and destruction in situ 2 . Schistosome granuloma formation as seen in the infected host is a complex immunological response probably involving several synergistic mechanisms 3 . In experimental anamnestic granulomas of mice, the augmented and accelerated cell response is mediated by delayed hypersensitivity 4 and is partly suppressed by immunosuppressive drugs, neonatal thymectomy, ALS (antilymphocyte serum) and X-irradiation 5–8 ; it is slightly inhibited by ellagic acid 9 . Soluble egg antigens have been obtained from Schistosome eggs by phosphate buffered saline (PBS) extraction and ultra-centrifugation which enhance granuloma formation around schistosome eggs in mice and induce dermal reactivity in the mouse footpad (unpublished work of D. L. Boros and K. S. Warren). This material is currently being analysed immunochemically.
ISSN:0028-0836
1476-4687
DOI:10.1038/229199a0