2-(2-Ethoxyphenoxymethyl)tetra-hydro-1,4-oxazine Hydrochloride, a Potential Psychotropic Agent

WE have been investigating the pharmacological properties of a series of aryloxymethyltetrahydro-1,4-oxazines of the general formula (I): where Ar is an aromatic group (optionally substituted), and R is hydrogen or an alkyl group. The series arose from attempts to exploit the observed activity of th...

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Bibliographic Details
Published in:Nature (London) 1972-07, Vol.238 (5360), p.157-158
Main Authors: MALLION, K. B, TODD, A. H, TURNER, R. W, BAINBRIDGE, J. G, GREENWOOD, D. T, MADINAVEITIA, J, SOMERVILLE, A. R, WHITTLE, B. A
Format: Article
Language:English
Subjects:
Humanities and Social Sciences
letter
multidisciplinary
Science
Science (multidisciplinary)
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Summary:WE have been investigating the pharmacological properties of a series of aryloxymethyltetrahydro-1,4-oxazines of the general formula (I): where Ar is an aromatic group (optionally substituted), and R is hydrogen or an alkyl group. The series arose from attempts to exploit the observed activity of the aryloxypropanol-amine series of β-adrenergic blocking agents on the central nervous system of laboratory animals 1,2 . To obtain more lipophilic compounds, a two-carbon bridge was inserted between the amine nitrogen and hydroxyl group, leading to compounds of the formula (I).
ISSN:0028-0836
1476-4687
DOI:10.1038/238157a0