Radiation-induced nondisjunction in mouse oocytes

BECAUSE chromosomal trisomy is found with relatively high frequencies in congenital malformations and spontaneous abortions in man, the aetiology of abnormal segregation is a pressing problem. One possible factor is exposure of women to diagnostic X rays 1–8 . Experiments with Drosophila melanogaste...

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Bibliographic Details
Published in:Nature (London) 1974-08, Vol.250 (5467), p.601-602
Main Authors: UCHIDA, IRENE A., LEE, C. P. VIOLA
Format: Article
Language:English
Subjects:
Animals
Cesium Isotopes
Chromosome Aberrations
Dose-Response Relationship, Radiation
Female
Humanities and Social Sciences
Hybridization, Genetic
letter
Meiosis - radiation effects
Mice
Mice, Inbred C3H
Mice, Inbred ICR
multidisciplinary
Ovum - radiation effects
Radiation Effects
Radioisotopes
Science
Science (multidisciplinary)
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Summary:BECAUSE chromosomal trisomy is found with relatively high frequencies in congenital malformations and spontaneous abortions in man, the aetiology of abnormal segregation is a pressing problem. One possible factor is exposure of women to diagnostic X rays 1–8 . Experiments with Drosophila melanogaster indicate that nondisjunction can be induced by exposure of females to X rays 9,10 especially if the flies are old 11,12 . Russell 13 reported an increase in induced monosomy in mice by examining the progeny of matings with sex-linked markers. But many aneuploids may be lethal and the dosages used by Russell were large enough to cause loss of chromosomes by breakage. Recent advances in the technique of culturing mouse oocytes in vitro (ref. 14, modified by E. P. Evans and C. E. Ford) have made it possible to circumvent these difficulties by examining meiotic chromosomes in second metaphase. The following experiment was designed to examine the effect of low doses of whole-body irradiation on chromosome segregation during first meiotic division in the oocytes of young female mice.
ISSN:0028-0836
1476-4687
DOI:10.1038/250601a0