α-Chain contacts in the polymerization of sickle haemoglobin

Five new double-mutant haemoglobins composed of β s chains and α chains with different substitutions, which are located at the surface of the tetramer, have been prepared. Although all the hybrids are more soluble than deoxyhaemoglobin S, the individual differences between these molecules make it po...

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Bibliographic Details
Published in:Nature (London) 1976-03, Vol.260 (5548), p.219-221
Main Authors: Benesch, Ruth E, Yung, Suzanna, Benesch, Reinhold, Mack, John, Schneider, Rose G
Format: Article
Language:English
Subjects:
Humanities and Social Sciences
multidisciplinary
Science
Science (multidisciplinary)
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Summary:Five new double-mutant haemoglobins composed of β s chains and α chains with different substitutions, which are located at the surface of the tetramer, have been prepared. Although all the hybrids are more soluble than deoxyhaemoglobin S, the individual differences between these molecules make it possible to evaluate several regions on the α chains for intermolecular contacts in the polymerisation of deoxyhaemoglobin S.
ISSN:0028-0836
1476-4687
DOI:10.1038/260219a0