Radiation-induced nondisjunction in oocytes of aged mice

SOME human epidemiological studies 1–4 suggest that there may be an association between nondisjunction and preconception exposure to abdominal X rays in women. This response to radiation appears to increase with age 2,4 . To test this hypothesis, experimental evidence was sought by examining second...

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Bibliographic Details
Published in:Nature (London) 1977-01, Vol.265 (5590), p.186-187
Main Authors: UCHIDA, IRENE A., FREEMAN, C. P. VIOLA
Format: Article
Language:English
Subjects:
Aging
Animals
Chromatids - radiation effects
Chromosome Aberrations
Female
Gamma Rays
Humanities and Social Sciences
letter
Meiosis - radiation effects
Mice
multidisciplinary
Oocytes - radiation effects
Oogenesis - radiation effects
Ovum - radiation effects
Radiation Genetics
Radiation, Ionizing
Science
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Summary:SOME human epidemiological studies 1–4 suggest that there may be an association between nondisjunction and preconception exposure to abdominal X rays in women. This response to radiation appears to increase with age 2,4 . To test this hypothesis, experimental evidence was sought by examining second metaphase chromosomes of cultured oocytes of mice. In the previous experiment 5 , abnormal segregation was induced in young mice, aged 3–6 months, by exposing them to a low dose of whole body gamma irradiation from a 137 Cs source. We have now found that radiosensitivity increases with age.
ISSN:0028-0836
1476-4687
DOI:10.1038/265186a0