Possible regulatory function of acetylcholine receptor in maintenance of retinotectal synapses

α -Neurotoxins bind to cholinergic receptor, block transmission, and induce sprouting of retinal terminals in the toad tectum. New connections retain an orderliness that suggests a selective affinity between presynaptic terminals. The results suggest that postsynaptic cells exert a control, associat...

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Bibliographic Details
Published in:Nature (London) 1977-09, Vol.269 (5625), p.218-222
Main Author: Freeman, John A
Format: Article
Language:English
Subjects:
Acetylcholine - metabolism
Animals
Bufo marinus
Bungarotoxins - pharmacology
Humanities and Social Sciences
multidisciplinary
Receptors, Cholinergic - drug effects
Receptors, Cholinergic - physiology
Retina - drug effects
Retina - ultrastructure
Science
Science (multidisciplinary)
Synapses - drug effects
Synapses - ultrastructure
Synaptic Transmission - drug effects
Tectum Mesencephali - drug effects
Tectum Mesencephali - ultrastructure
Time Factors
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Description
Summary:α -Neurotoxins bind to cholinergic receptor, block transmission, and induce sprouting of retinal terminals in the toad tectum. New connections retain an orderliness that suggests a selective affinity between presynaptic terminals. The results suggest that postsynaptic cells exert a control, associated with receptors, on the growth of presynaptic terminals and on the maintenance of their synaptic connections.
ISSN:0028-0836
1476-4687
DOI:10.1038/269218a0