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Possible regulatory function of acetylcholine receptor in maintenance of retinotectal synapses
α -Neurotoxins bind to cholinergic receptor, block transmission, and induce sprouting of retinal terminals in the toad tectum. New connections retain an orderliness that suggests a selective affinity between presynaptic terminals. The results suggest that postsynaptic cells exert a control, associat...
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| Published in: | Nature (London) 1977-09, Vol.269 (5625), p.218-222 |
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| Main Author: | |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c334t-509d449f1d21f93007ea6c4fb1b63ddd137bef5c401af140125dc53b55a80d983 |
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| cites | cdi_FETCH-LOGICAL-c334t-509d449f1d21f93007ea6c4fb1b63ddd137bef5c401af140125dc53b55a80d983 |
| container_end_page | 222 |
| container_issue | 5625 |
| container_start_page | 218 |
| container_title | Nature (London) |
| container_volume | 269 |
| creator | Freeman, John A |
| description | α
-Neurotoxins bind to cholinergic receptor, block transmission, and induce sprouting of retinal terminals in the toad tectum. New connections retain an orderliness that suggests a selective affinity between presynaptic terminals. The results suggest that postsynaptic cells exert a control, associated with receptors, on the growth of presynaptic terminals and on the maintenance of their synaptic connections. |
| doi_str_mv | 10.1038/269218a0 |
| format | article |
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-Neurotoxins bind to cholinergic receptor, block transmission, and induce sprouting of retinal terminals in the toad tectum. New connections retain an orderliness that suggests a selective affinity between presynaptic terminals. The results suggest that postsynaptic cells exert a control, associated with receptors, on the growth of presynaptic terminals and on the maintenance of their synaptic connections.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/269218a0</identifier><identifier>PMID: 201850</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Acetylcholine - metabolism ; Animals ; Bufo marinus ; Bungarotoxins - pharmacology ; Humanities and Social Sciences ; multidisciplinary ; Receptors, Cholinergic - drug effects ; Receptors, Cholinergic - physiology ; Retina - drug effects ; Retina - ultrastructure ; Science ; Science (multidisciplinary) ; Synapses - drug effects ; Synapses - ultrastructure ; Synaptic Transmission - drug effects ; Tectum Mesencephali - drug effects ; Tectum Mesencephali - ultrastructure ; Time Factors</subject><ispartof>Nature (London), 1977-09, Vol.269 (5625), p.218-222</ispartof><rights>Springer Nature Limited 1977</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c334t-509d449f1d21f93007ea6c4fb1b63ddd137bef5c401af140125dc53b55a80d983</citedby><cites>FETCH-LOGICAL-c334t-509d449f1d21f93007ea6c4fb1b63ddd137bef5c401af140125dc53b55a80d983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2725,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/201850$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Freeman, John A</creatorcontrib><title>Possible regulatory function of acetylcholine receptor in maintenance of retinotectal synapses</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>α
-Neurotoxins bind to cholinergic receptor, block transmission, and induce sprouting of retinal terminals in the toad tectum. New connections retain an orderliness that suggests a selective affinity between presynaptic terminals. The results suggest that postsynaptic cells exert a control, associated with receptors, on the growth of presynaptic terminals and on the maintenance of their synaptic connections.</description><subject>Acetylcholine - metabolism</subject><subject>Animals</subject><subject>Bufo marinus</subject><subject>Bungarotoxins - pharmacology</subject><subject>Humanities and Social Sciences</subject><subject>multidisciplinary</subject><subject>Receptors, Cholinergic - drug effects</subject><subject>Receptors, Cholinergic - physiology</subject><subject>Retina - drug effects</subject><subject>Retina - ultrastructure</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Synapses - drug effects</subject><subject>Synapses - ultrastructure</subject><subject>Synaptic Transmission - drug effects</subject><subject>Tectum Mesencephali - drug effects</subject><subject>Tectum Mesencephali - ultrastructure</subject><subject>Time Factors</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><recordid>eNpt0DtPwzAUBWAL8SoFiR-AUEYYAtexnTgjqnhJlWCAlcixr0uq1KlsZ8i_J1V4LCz2cD4d2YeQcwo3FJi8zfIyo1LBHplRXuQpz2WxT2YAmUxBsvyYnISwBgBBC35EDjOgUsCMfLx2ITR1i4nHVd-q2Pkhsb3Tselc0tlEaYxDqz-7tnE7pHE7mqRxyUY1LqJTTuMOeoyN6yLqqNokDE5tA4ZTcmBVG_Ds-56T94f7t8VTunx5fF7cLVPNGI-pgNJwXlpqMmpLBlCgyjW3Na1zZoyhrKjRCs2BKkvHMxNGC1YLoSSYUrI5uZp6tR__49FWW99slB8qCtVuoOpnoJFeTHTb1xs0v3BaZIyvpziMgVuhr9Zd7934-P-qLifrVOw9_lX9gC-9MXk_</recordid><startdate>19770915</startdate><enddate>19770915</enddate><creator>Freeman, John A</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19770915</creationdate><title>Possible regulatory function of acetylcholine receptor in maintenance of retinotectal synapses</title><author>Freeman, John A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c334t-509d449f1d21f93007ea6c4fb1b63ddd137bef5c401af140125dc53b55a80d983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Acetylcholine - metabolism</topic><topic>Animals</topic><topic>Bufo marinus</topic><topic>Bungarotoxins - pharmacology</topic><topic>Humanities and Social Sciences</topic><topic>multidisciplinary</topic><topic>Receptors, Cholinergic - drug effects</topic><topic>Receptors, Cholinergic - physiology</topic><topic>Retina - drug effects</topic><topic>Retina - ultrastructure</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Synapses - drug effects</topic><topic>Synapses - ultrastructure</topic><topic>Synaptic Transmission - drug effects</topic><topic>Tectum Mesencephali - drug effects</topic><topic>Tectum Mesencephali - ultrastructure</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Freeman, John A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Freeman, John A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Possible regulatory function of acetylcholine receptor in maintenance of retinotectal synapses</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1977-09-15</date><risdate>1977</risdate><volume>269</volume><issue>5625</issue><spage>218</spage><epage>222</epage><pages>218-222</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>α
-Neurotoxins bind to cholinergic receptor, block transmission, and induce sprouting of retinal terminals in the toad tectum. New connections retain an orderliness that suggests a selective affinity between presynaptic terminals. The results suggest that postsynaptic cells exert a control, associated with receptors, on the growth of presynaptic terminals and on the maintenance of their synaptic connections.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>201850</pmid><doi>10.1038/269218a0</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1977-09, Vol.269 (5625), p.218-222 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_crossref_primary_10_1038_269218a0 |
| source | Nature |
| subjects | Acetylcholine - metabolism Animals Bufo marinus Bungarotoxins - pharmacology Humanities and Social Sciences multidisciplinary Receptors, Cholinergic - drug effects Receptors, Cholinergic - physiology Retina - drug effects Retina - ultrastructure Science Science (multidisciplinary) Synapses - drug effects Synapses - ultrastructure Synaptic Transmission - drug effects Tectum Mesencephali - drug effects Tectum Mesencephali - ultrastructure Time Factors |
| title | Possible regulatory function of acetylcholine receptor in maintenance of retinotectal synapses |
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