Potential for variability through multiple gene products of bacteriophage ΦX174

The small single-stranded DNA phages ΦX174 and S13 produce multiple products of certain phage genes, as observed by electrophoresis on SDS–polyacrylamide slab gels. Two A protein products, two A * products and four G products are observed. The multiple gene products may arise from multiple sites for...

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Bibliographic Details
Published in:Nature (London) 1978-07, Vol.274 (5666), p.34-37
Main Authors: Pollock, Thomas J, Tessman, Irwin, Tessman, Ethel S
Format: Article
Language:English
Subjects:
Humanities and Social Sciences
multidisciplinary
Science
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Summary:The small single-stranded DNA phages ΦX174 and S13 produce multiple products of certain phage genes, as observed by electrophoresis on SDS–polyacrylamide slab gels. Two A protein products, two A * products and four G products are observed. The multiple gene products may arise from multiple sites for initiation or termination of translation, or by protein modification. Some of the variant products may provide a substitute for heterozygosity without a concomitant increase in the size of the genome.
ISSN:0028-0836
1476-4687
DOI:10.1038/274034a0