A pseudo α -helix from poly( α -isobutyl-L-aspartate), a nylon-3 derivative

Derivatives of nylon-3, with the general formula given in Fig. 1, crystallize as extended chains, producing sheets similar to those found in polypeptides in the β -conformation 1–3 . Nylon-3 itself (R=H, poly- β -alanine) crystallizes as extended chains 4 . However, given the similarity of the chemi...

Full description

Saved in:
Bibliographic Details
Published in:Nature (London) 1984-09, Vol.311 (5981), p.53-54
Main Authors: Fernández-Santín, J. M, Aymamí, J, Rodríguez-Galán, A, Muñoz-Guerra, S, Subirana, J. A
Format: Article
Language:English
Subjects:
Humanities and Social Sciences
letter
multidisciplinary
Science
Science (multidisciplinary)
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c284t-facd7dd9342ccc282c9054994fcf1877e2fe4e3c87810d88100b596991337c673
cites cdi_FETCH-LOGICAL-c284t-facd7dd9342ccc282c9054994fcf1877e2fe4e3c87810d88100b596991337c673
container_end_page 54
container_issue 5981
container_start_page 53
container_title Nature (London)
container_volume 311
creator Fernández-Santín, J. M
Aymamí, J
Rodríguez-Galán, A
Muñoz-Guerra, S
Subirana, J. A
description Derivatives of nylon-3, with the general formula given in Fig. 1, crystallize as extended chains, producing sheets similar to those found in polypeptides in the β -conformation 1–3 . Nylon-3 itself (R=H, poly- β -alanine) crystallizes as extended chains 4 . However, given the similarity of the chemical structure, we decided to search for conformations related to the α -helix in this type of compounds. We show here that the nylon-3 derivative poly( α -isobutyl-L-aspartate) can adopt a helical structure similar to an α -helix. The turn has 3.25 residues, equicalent to 13 main chain atoms, whereas the α -helix has 10.8 atoms per turn. This is the first time that a helical structure has been observed in a polyamide, other than in the conventional polypeptides and proteins.
doi_str_mv 10.1038/311053a0
format article
fullrecord <record><control><sourceid>nature_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1038_311053a0</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>311053a0</sourcerecordid><originalsourceid>FETCH-LOGICAL-c284t-facd7dd9342ccc282c9054994fcf1877e2fe4e3c87810d88100b596991337c673</originalsourceid><addsrcrecordid>eNpt0N9KwzAUBvAgCs4p-ASSyw2MnjRpk1yO4T-oeKPXJUsT7eiakrTDPpYv4jNZne7Km3Pg8OPj8CF0TuGKApPXjFJImYYDNKFcZIRnUhyiCUAiCUiWHaOTGNcAkFLBJ-hxgdto-9Ljzw9M3mxdvWMX_Aa3vh5mP8cq-lXfDTXJiY6tDp3u7PwSa9wMtW8Iw6UN1VZ31daeoiOn62jPfvcUvdzePC_vSf5097Bc5MQkknfEaVOKslSMJ8aMp8QoSLlS3BlHpRA2cZZbZqSQFEo5DlilKlOKMiZMJtgUzXa5JvgYg3VFG6qNDkNBofiuofirYaTzHY0jaV5tKNa-D8343X_2Ymcb3fXB7kP34Atjq2YA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>A pseudo α -helix from poly( α -isobutyl-L-aspartate), a nylon-3 derivative</title><source>Nature Journals Online</source><creator>Fernández-Santín, J. M ; Aymamí, J ; Rodríguez-Galán, A ; Muñoz-Guerra, S ; Subirana, J. A</creator><creatorcontrib>Fernández-Santín, J. M ; Aymamí, J ; Rodríguez-Galán, A ; Muñoz-Guerra, S ; Subirana, J. A</creatorcontrib><description>Derivatives of nylon-3, with the general formula given in Fig. 1, crystallize as extended chains, producing sheets similar to those found in polypeptides in the β -conformation 1–3 . Nylon-3 itself (R=H, poly- β -alanine) crystallizes as extended chains 4 . However, given the similarity of the chemical structure, we decided to search for conformations related to the α -helix in this type of compounds. We show here that the nylon-3 derivative poly( α -isobutyl-L-aspartate) can adopt a helical structure similar to an α -helix. The turn has 3.25 residues, equicalent to 13 main chain atoms, whereas the α -helix has 10.8 atoms per turn. This is the first time that a helical structure has been observed in a polyamide, other than in the conventional polypeptides and proteins.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/311053a0</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Humanities and Social Sciences ; letter ; multidisciplinary ; Science ; Science (multidisciplinary)</subject><ispartof>Nature (London), 1984-09, Vol.311 (5981), p.53-54</ispartof><rights>Springer Nature Limited 1984</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c284t-facd7dd9342ccc282c9054994fcf1877e2fe4e3c87810d88100b596991337c673</citedby><cites>FETCH-LOGICAL-c284t-facd7dd9342ccc282c9054994fcf1877e2fe4e3c87810d88100b596991337c673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2727,27924,27925</link.rule.ids></links><search><creatorcontrib>Fernández-Santín, J. M</creatorcontrib><creatorcontrib>Aymamí, J</creatorcontrib><creatorcontrib>Rodríguez-Galán, A</creatorcontrib><creatorcontrib>Muñoz-Guerra, S</creatorcontrib><creatorcontrib>Subirana, J. A</creatorcontrib><title>A pseudo α -helix from poly( α -isobutyl-L-aspartate), a nylon-3 derivative</title><title>Nature (London)</title><addtitle>Nature</addtitle><description>Derivatives of nylon-3, with the general formula given in Fig. 1, crystallize as extended chains, producing sheets similar to those found in polypeptides in the β -conformation 1–3 . Nylon-3 itself (R=H, poly- β -alanine) crystallizes as extended chains 4 . However, given the similarity of the chemical structure, we decided to search for conformations related to the α -helix in this type of compounds. We show here that the nylon-3 derivative poly( α -isobutyl-L-aspartate) can adopt a helical structure similar to an α -helix. The turn has 3.25 residues, equicalent to 13 main chain atoms, whereas the α -helix has 10.8 atoms per turn. This is the first time that a helical structure has been observed in a polyamide, other than in the conventional polypeptides and proteins.</description><subject>Humanities and Social Sciences</subject><subject>letter</subject><subject>multidisciplinary</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><recordid>eNpt0N9KwzAUBvAgCs4p-ASSyw2MnjRpk1yO4T-oeKPXJUsT7eiakrTDPpYv4jNZne7Km3Pg8OPj8CF0TuGKApPXjFJImYYDNKFcZIRnUhyiCUAiCUiWHaOTGNcAkFLBJ-hxgdto-9Ljzw9M3mxdvWMX_Aa3vh5mP8cq-lXfDTXJiY6tDp3u7PwSa9wMtW8Iw6UN1VZ31daeoiOn62jPfvcUvdzePC_vSf5097Bc5MQkknfEaVOKslSMJ8aMp8QoSLlS3BlHpRA2cZZbZqSQFEo5DlilKlOKMiZMJtgUzXa5JvgYg3VFG6qNDkNBofiuofirYaTzHY0jaV5tKNa-D8343X_2Ymcb3fXB7kP34Atjq2YA</recordid><startdate>19840906</startdate><enddate>19840906</enddate><creator>Fernández-Santín, J. M</creator><creator>Aymamí, J</creator><creator>Rodríguez-Galán, A</creator><creator>Muñoz-Guerra, S</creator><creator>Subirana, J. A</creator><general>Nature Publishing Group UK</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19840906</creationdate><title>A pseudo α -helix from poly( α -isobutyl-L-aspartate), a nylon-3 derivative</title><author>Fernández-Santín, J. M ; Aymamí, J ; Rodríguez-Galán, A ; Muñoz-Guerra, S ; Subirana, J. A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c284t-facd7dd9342ccc282c9054994fcf1877e2fe4e3c87810d88100b596991337c673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Humanities and Social Sciences</topic><topic>letter</topic><topic>multidisciplinary</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fernández-Santín, J. M</creatorcontrib><creatorcontrib>Aymamí, J</creatorcontrib><creatorcontrib>Rodríguez-Galán, A</creatorcontrib><creatorcontrib>Muñoz-Guerra, S</creatorcontrib><creatorcontrib>Subirana, J. A</creatorcontrib><collection>CrossRef</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fernández-Santín, J. M</au><au>Aymamí, J</au><au>Rodríguez-Galán, A</au><au>Muñoz-Guerra, S</au><au>Subirana, J. A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A pseudo α -helix from poly( α -isobutyl-L-aspartate), a nylon-3 derivative</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><date>1984-09-06</date><risdate>1984</risdate><volume>311</volume><issue>5981</issue><spage>53</spage><epage>54</epage><pages>53-54</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>Derivatives of nylon-3, with the general formula given in Fig. 1, crystallize as extended chains, producing sheets similar to those found in polypeptides in the β -conformation 1–3 . Nylon-3 itself (R=H, poly- β -alanine) crystallizes as extended chains 4 . However, given the similarity of the chemical structure, we decided to search for conformations related to the α -helix in this type of compounds. We show here that the nylon-3 derivative poly( α -isobutyl-L-aspartate) can adopt a helical structure similar to an α -helix. The turn has 3.25 residues, equicalent to 13 main chain atoms, whereas the α -helix has 10.8 atoms per turn. This is the first time that a helical structure has been observed in a polyamide, other than in the conventional polypeptides and proteins.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><doi>10.1038/311053a0</doi><tpages>2</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0028-0836
ispartof Nature (London), 1984-09, Vol.311 (5981), p.53-54
issn 0028-0836
1476-4687
language eng
recordid cdi_crossref_primary_10_1038_311053a0
source Nature Journals Online
subjects Humanities and Social Sciences
letter
multidisciplinary
Science
Science (multidisciplinary)
title A pseudo α -helix from poly( α -isobutyl-L-aspartate), a nylon-3 derivative
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T16%3A40%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-nature_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20pseudo%20%CE%B1%20-helix%20from%20poly(%20%CE%B1%20-isobutyl-L-aspartate),%20a%20nylon-3%20derivative&rft.jtitle=Nature%20(London)&rft.au=Fern%C3%A1ndez-Sant%C3%ADn,%20J.%20M&rft.date=1984-09-06&rft.volume=311&rft.issue=5981&rft.spage=53&rft.epage=54&rft.pages=53-54&rft.issn=0028-0836&rft.eissn=1476-4687&rft_id=info:doi/10.1038/311053a0&rft_dat=%3Cnature_cross%3E311053a0%3C/nature_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c284t-facd7dd9342ccc282c9054994fcf1877e2fe4e3c87810d88100b596991337c673%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true