Predicting Age-Specific Dosing of Antipsychotics

Antipsychotic medications are the standard of care for both acute and maintenance treatment of schizophrenia, the latter requiring an indefinite treatment across a patient's life span. However, dosing and tolerability of antipsychotics have been studied primarily in younger patients, and very l...

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Bibliographic Details
Published in:Clinical pharmacology and therapeutics 2009-10, Vol.86 (4), p.360-362
Main Authors: Uchida, H, Pollock, B G, Bies, R R, Mamo, D C
Format: Article
Language:English
Subjects:
Aging
Antipsychotic Agents - administration & dosage
Antipsychotic Agents - adverse effects
Antipsychotic Agents - therapeutic use
Basal Ganglia Diseases - chemically induced
Dose-Response Relationship, Drug
Humans
Positron-Emission Tomography
Receptors, Dopamine - metabolism
Schizophrenia - diagnostic imaging
Schizophrenia - drug therapy
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Summary:Antipsychotic medications are the standard of care for both acute and maintenance treatment of schizophrenia, the latter requiring an indefinite treatment across a patient's life span. However, dosing and tolerability of antipsychotics have been studied primarily in younger patients, and very limited data are available for age‐ and phase‐specific dosing. This leaves the clinician with no guidance on dose adjustment as patients grow older—an issue of critical importance, especially in light of recent concerns about increased morbidity and mortality associated with antipsychotics. Clinical Pharmacology & Therapeutics (2009) 86 4, 360–362. doi:10.1038/clpt.2009.133
ISSN:0009-9236
1532-6535
DOI:10.1038/clpt.2009.133