Safety of Hypercapnic Challenge: Cardiovascular and Neurologic Considerations

The hemodynamic, cerebrovascular, and neurologic effects of hypercapnia with 4% and 6% CO2 were retrospectively reviewed in 217 patients referred for regional CBF (rCBF) procedures. Inhalation of CO2 significantly increased rCBF, blood pressure, and pulse from baseline. The findings suggest a higher...

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Bibliographic Details
Published in:Journal of cerebral blood flow and metabolism 1991-11, Vol.11 (6), p.1036-1040
Main Authors: Gitelman, Darren R., Prohovnik, Isak, Tatemichi, Thomas K.
Format: Article
Language:English
Subjects:
Administration, Inhalation
Biological and medical sciences
Blood Pressure - drug effects
Carbon Dioxide - adverse effects
Carbon Dioxide - pharmacology
Cardiovascular System - drug effects
Cerebrovascular Circulation - drug effects
Humans
Medical sciences
Nervous System - physiopathology
Neurology
Retrospective Studies
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Summary:The hemodynamic, cerebrovascular, and neurologic effects of hypercapnia with 4% and 6% CO2 were retrospectively reviewed in 217 patients referred for regional CBF (rCBF) procedures. Inhalation of CO2 significantly increased rCBF, blood pressure, and pulse from baseline. The findings suggest a higher incidence of side effects with 6% CO2 concentration and an equivalent vasoreactivity to 4%. We recommend the use of 4% CO2 for hypercapnic stimulation, and present safety guidelines for its use.
ISSN:0271-678X
1559-7016
DOI:10.1038/jcbfm.1991.172