Cerebral 5-HT 2A Receptor and Serotonin Transporter Binding in Humans Are Not Affected by the val66met BDNF Polymorphism Status or Blood BDNF Levels

Recent studies have proposed an interrelation between the brain-derived neurotrophic factor (BDNF) val66met polymorphism and the serotonin system. In this study, we investigated whether the BDNF val66met polymorphism or blood BDNF levels are associated with cerebral 5-hydroxytryptamine 2A (5-HT 2A )...

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Bibliographic Details
Published in:Journal of cerebral blood flow and metabolism 2010-08, Vol.30 (11), p.e1-e7
Main Authors: Klein, Anders Bue, Trajkovska, Viktorija, Erritzoe, David, Haugbol, Steven, Madsen, Jacob, Baaré, William, Aznar, Susana, Knudsen, Gitte M
Format: Article
Language:English
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Summary:Recent studies have proposed an interrelation between the brain-derived neurotrophic factor (BDNF) val66met polymorphism and the serotonin system. In this study, we investigated whether the BDNF val66met polymorphism or blood BDNF levels are associated with cerebral 5-hydroxytryptamine 2A (5-HT 2A ) receptor or serotonin transporter (SERT) binding in healthy subjects. No statistically significant differences in 5-HT 2A receptor or SERT binding were found between the val/val and met carriers, nor were blood BDNF values associated with SERT binding or 5-HT 2A receptor binding. In conclusion, val66met BDNF polymorphism status is not associated with changes in the serotonergic system. Moreover, BDNF levels in blood do not correlate with either 5-HT 2A or SERT binding.
ISSN:0271-678X
1559-7016
DOI:10.1038/jcbfm.2010.114