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Monoclonal Antibodies Specific for Human IgE-Producing B Cells: A Potential Therapeutic for IgE-Mediated Allergic Diseases
Monoclonal antibodies (MAbs) specific for surface antigens of lymphocytes are being used to target and deplete tumorous or normal lymphocytes in vivo . Here, we report evidence for the existence of antigenic epitopes on IgE that are accessible on IgE-secreting B cells but not on other cells bearing...
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| Published in: | Bio/Technology 1990-02, Vol.8 (2), p.122-126 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c483t-ed69823a753dec053cb27569b798c206753654e6fe528c46d68ec8e0664b21cd3 |
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| cites | cdi_FETCH-LOGICAL-c483t-ed69823a753dec053cb27569b798c206753654e6fe528c46d68ec8e0664b21cd3 |
| container_end_page | 126 |
| container_issue | 2 |
| container_start_page | 122 |
| container_title | Bio/Technology |
| container_volume | 8 |
| creator | Chang, Tse Wen Davis, Frances M Sun, Nai-Chau Sun, Cecily R. Y MacGlashan, Donald W Hamilton, Robert G |
| description | Monoclonal antibodies (MAbs) specific for surface antigens of lymphocytes are being used to target and deplete tumorous or normal lymphocytes
in vivo
. Here, we report evidence for the existence of antigenic epitopes on IgE that are accessible on IgE-secreting B cells but not on other cells bearing IgE. Among 42 murine MAbs specific for human IgE, two were shown by fluorescence flow cytometric analyses to bind to IgE-secreting cell lines but not to IgE bound to high-affinity IgE. Fc receptors (Fc∈RI) on basophils or low-affinity IgE receptors (Fc∈RII) on other cell types. Neither could they induce histamine release from basophils of various donors even under very permissive conditions. These antibodies may be useful for targeting IgE-secreting B cells in patients suffering from IgE-mediated allergies. |
| doi_str_mv | 10.1038/nbt0290-122 |
| format | article |
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in vivo
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in vivo
. Here, we report evidence for the existence of antigenic epitopes on IgE that are accessible on IgE-secreting B cells but not on other cells bearing IgE. Among 42 murine MAbs specific for human IgE, two were shown by fluorescence flow cytometric analyses to bind to IgE-secreting cell lines but not to IgE bound to high-affinity IgE. Fc receptors (Fc∈RI) on basophils or low-affinity IgE receptors (Fc∈RII) on other cell types. Neither could they induce histamine release from basophils of various donors even under very permissive conditions. These antibodies may be useful for targeting IgE-secreting B cells in patients suffering from IgE-mediated allergies.</description><subject>Agriculture</subject><subject>Animals</subject><subject>Antibodies, Anti-Idiotypic - immunology</subject><subject>Antibodies, Anti-Idiotypic - therapeutic use</subject><subject>Antibodies, immunoglobulins</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Antibodies, Monoclonal - therapeutic use</subject><subject>Antibody Specificity</subject><subject>Antigens, Differentiation, B-Lymphocyte - metabolism</subject><subject>B-Lymphocytes - immunology</subject><subject>B-Lymphocytes - secretion</subject><subject>Basophils - secretion</subject><subject>Bioinformatics</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering/Biotechnology</subject><subject>Biomedicine</subject><subject>Biotechnology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Histamine Release</subject><subject>Humans</subject><subject>Hypersensitivity, Immediate - immunology</subject><subject>Hypersensitivity, Immediate - therapy</subject><subject>Immunoglobulin E - immunology</subject><subject>Immunoglobulin E - secretion</subject><subject>Immunoglobulin E - therapeutic use</subject><subject>Immunotherapy</subject><subject>Life Sciences</subject><subject>Mice</subject><subject>Molecular immunology</subject><subject>Monoclonal antibodies</subject><subject>Receptors, Fc - metabolism</subject><subject>Receptors, IgE</subject><subject>research-paper</subject><issn>0733-222X</issn><issn>1087-0156</issn><issn>2331-3684</issn><issn>1546-1696</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><recordid>eNp1kr9v1DAYhq0KVK4HEzOSGdqlBPwjcexu12uhlVpRiVZiixz7y-EqZ1_tZKB_PT4loixMlvw-32PrtRF6T8lnSrj84tuBMEUKytgBWjDOacGFLF-hBak5LxhjP9-go5QeCSlrwcpDdEi5UErRBXq-DT6YPnjd45UfXBusg4R_7MC4zhnchYivxq32-HpzWdzFYEfj_Aaf4zX0fTrDK3wXBsiTWXD_C6LewTjMg_uRW7BOD2Dxqu8hbnJy4RLoBOktet3pPsG7eV2ih6-X9-ur4ub7t-v16qYwpeRDAVYoybiuK27BkIqbltWVUG2tpGFE5H1RlSA6qJg0pbBCgpFAhChbRo3lS3QyeXcxPI2Qhmbrksm31x7CmBpJCCUqV7VEpxNoYkgpQtfsotvq-LuhpNk33cxNN7npTH-YtWO7BfvCTtXm_HjOdTK676L2xqUXTPEs4XvPp4lLOfIbiM1jGGN-j_SfYz9OuNfDGOGv759PwP8Amw-fXQ</recordid><startdate>19900201</startdate><enddate>19900201</enddate><creator>Chang, Tse Wen</creator><creator>Davis, Frances M</creator><creator>Sun, Nai-Chau</creator><creator>Sun, Cecily R. Y</creator><creator>MacGlashan, Donald W</creator><creator>Hamilton, Robert G</creator><general>Nature Publishing Group US</general><general>Nature Publications</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900201</creationdate><title>Monoclonal Antibodies Specific for Human IgE-Producing B Cells: A Potential Therapeutic for IgE-Mediated Allergic Diseases</title><author>Chang, Tse Wen ; Davis, Frances M ; Sun, Nai-Chau ; Sun, Cecily R. Y ; MacGlashan, Donald W ; Hamilton, Robert G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-ed69823a753dec053cb27569b798c206753654e6fe528c46d68ec8e0664b21cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Agriculture</topic><topic>Animals</topic><topic>Antibodies, Anti-Idiotypic - immunology</topic><topic>Antibodies, Anti-Idiotypic - therapeutic use</topic><topic>Antibodies, immunoglobulins</topic><topic>Antibodies, Monoclonal - immunology</topic><topic>Antibodies, Monoclonal - therapeutic use</topic><topic>Antibody Specificity</topic><topic>Antigens, Differentiation, B-Lymphocyte - metabolism</topic><topic>B-Lymphocytes - immunology</topic><topic>B-Lymphocytes - secretion</topic><topic>Basophils - secretion</topic><topic>Bioinformatics</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedical Engineering/Biotechnology</topic><topic>Biomedicine</topic><topic>Biotechnology</topic><topic>Fundamental and applied biological sciences. 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in vivo
. Here, we report evidence for the existence of antigenic epitopes on IgE that are accessible on IgE-secreting B cells but not on other cells bearing IgE. Among 42 murine MAbs specific for human IgE, two were shown by fluorescence flow cytometric analyses to bind to IgE-secreting cell lines but not to IgE bound to high-affinity IgE. Fc receptors (Fc∈RI) on basophils or low-affinity IgE receptors (Fc∈RII) on other cell types. Neither could they induce histamine release from basophils of various donors even under very permissive conditions. These antibodies may be useful for targeting IgE-secreting B cells in patients suffering from IgE-mediated allergies.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>1369991</pmid><doi>10.1038/nbt0290-122</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0733-222X |
| ispartof | Bio/Technology, 1990-02, Vol.8 (2), p.122-126 |
| issn | 0733-222X 1087-0156 2331-3684 1546-1696 |
| language | eng |
| recordid | cdi_crossref_primary_10_1038_nbt0290_122 |
| source | Nature |
| subjects | Agriculture Animals Antibodies, Anti-Idiotypic - immunology Antibodies, Anti-Idiotypic - therapeutic use Antibodies, immunoglobulins Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use Antibody Specificity Antigens, Differentiation, B-Lymphocyte - metabolism B-Lymphocytes - immunology B-Lymphocytes - secretion Basophils - secretion Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Fundamental and applied biological sciences. Psychology Fundamental immunology Histamine Release Humans Hypersensitivity, Immediate - immunology Hypersensitivity, Immediate - therapy Immunoglobulin E - immunology Immunoglobulin E - secretion Immunoglobulin E - therapeutic use Immunotherapy Life Sciences Mice Molecular immunology Monoclonal antibodies Receptors, Fc - metabolism Receptors, IgE research-paper |
| title | Monoclonal Antibodies Specific for Human IgE-Producing B Cells: A Potential Therapeutic for IgE-Mediated Allergic Diseases |
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