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"Primatization" of Recombinant Antibodies for Immunotherapy of Human Diseases: A Macaque/Human Chimeric Antibody Against Human CD4
Immunoglobulin variable region genes from non-human primates, cynomolgus macaques, were shown to have 85%–98% homology with human immunoglobulin sequences and yet macaques are phylogenetically distant enough to respond against conserved human antigens. Immunoglobulin genes were isolated from monkeys...
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| Published in: | Bio/Technology 1992-11, Vol.10 (11), p.1455-1460 |
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| Main Authors: | , , , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c457t-4b0f22ba9d09a5671ee86cf99634f732d528e9884c30203fd3af6c16058ea3d73 |
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| cites | cdi_FETCH-LOGICAL-c457t-4b0f22ba9d09a5671ee86cf99634f732d528e9884c30203fd3af6c16058ea3d73 |
| container_end_page | 1460 |
| container_issue | 11 |
| container_start_page | 1455 |
| container_title | Bio/Technology |
| container_volume | 10 |
| creator | Newman, Roland Alberts, James Anderson, Darrell Carner, Kristin Heard, Cheryl Norton, Frank Raab, Ron Reff, Mitchell Shuey, Steve Hanna, Nabil |
| description | Immunoglobulin variable region genes from non-human primates, cynomolgus macaques, were shown to have 85%–98% homology with human immunoglobulin sequences and yet macaques are phylogenetically distant enough to respond against conserved human antigens. Immunoglobulin genes were isolated from monkeys immunized with human CD4 antigen and a human/monkey chimeric anti-CD4 antibody with 91–92% homology to human immunoglobulin framework regions was cloned and expressed. The antibody has an apparent affinity of 3.2 × 10
−11
M and exhibits potent immunosuppressive properties
in vitro. |
| doi_str_mv | 10.1038/nbt1192-1455 |
| format | article |
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−11
M and exhibits potent immunosuppressive properties
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−11
M and exhibits potent immunosuppressive properties
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Immunoglobulin genes were isolated from monkeys immunized with human CD4 antigen and a human/monkey chimeric anti-CD4 antibody with 91–92% homology to human immunoglobulin framework regions was cloned and expressed. The antibody has an apparent affinity of 3.2 × 10
−11
M and exhibits potent immunosuppressive properties
in vitro.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>1369023</pmid><doi>10.1038/nbt1192-1455</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0733-222X |
| ispartof | Bio/Technology, 1992-11, Vol.10 (11), p.1455-1460 |
| issn | 0733-222X 1087-0156 2331-3684 1546-1696 |
| language | eng |
| recordid | cdi_crossref_primary_10_1038_nbt1192_1455 |
| source | Nature |
| subjects | Agriculture Animals Antibodies, Monoclonal - analysis Antibodies, Monoclonal - therapeutic use Base Sequence Bioinformatics Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology CD4 Antigens - immunology Cloning, Molecular Humans Immunoglobulins - genetics Immunotherapy - methods Life Sciences Macaca fascicularis Molecular Sequence Data Recombinant Proteins - analysis Recombinant Proteins - therapeutic use research-paper Sequence Alignment Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid T-Lymphocytes - immunology |
| title | "Primatization" of Recombinant Antibodies for Immunotherapy of Human Diseases: A Macaque/Human Chimeric Antibody Against Human CD4 |
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