When ribosomes pick the structure

Anfinsen's principle tells us that the folded structure of a protein is determined solely by its sequence. Now, it has been shown that the rate at which a polypeptide chain is synthesized in the cell can affect which of two alternative folded structures it adopts.

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Bibliographic Details
Published in:Nature chemistry 2014-04, Vol.6 (5), p.378-379
Main Authors: Sivertsson, Elin M., Itzhaki, Laura S.
Format: Article
Language:English
Subjects:
639/638/45/470
Analytical Chemistry
Biochemistry
Chemistry
Chemistry/Food Science
Inorganic Chemistry
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Organic Chemistry
Physical Chemistry
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Description
Summary:Anfinsen's principle tells us that the folded structure of a protein is determined solely by its sequence. Now, it has been shown that the rate at which a polypeptide chain is synthesized in the cell can affect which of two alternative folded structures it adopts.
ISSN:1755-4330
1755-4349
DOI:10.1038/nchem.1926