Post-degradation forces kick in

Stem cells alter their morphology and differentiate to particular lineages in response to biophysical cues from the surrounding matrix. When the matrix is degradable, however, cell fate is morphology-independent and is directed by the traction forces that the cells actively apply after they have deg...

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Bibliographic Details
Published in:Nature materials 2013-04, Vol.12 (5), p.384-386
Main Authors: Vincent, Ludovic G., Engler, Adam J.
Format: Article
Language:English
Subjects:
639/301/54
Biomaterials
Condensed Matter Physics
Materials Science
Nanotechnology
news-and-views
Optical and Electronic Materials
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Summary:Stem cells alter their morphology and differentiate to particular lineages in response to biophysical cues from the surrounding matrix. When the matrix is degradable, however, cell fate is morphology-independent and is directed by the traction forces that the cells actively apply after they have degraded the matrix.
ISSN:1476-1122
1476-4660
DOI:10.1038/nmat3636