Low population serum microneutralization antibody titer against the predominating influenza A(H3N2) N121K virus during the severe influenza summer peak of Hong Kong in 2017

The 2017 Hong Kong influenza A(H3N2) summer season was unexpectedly severe. However, antigenic characterization of the 2017 circulating A(H3N2) viruses using ferret antisera did not show significant antigenic drift. We analyzed the hemagglutinin amino acid sequences of A(H3N2) virus circulating in H...

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Bibliographic Details
Published in:Emerging microbes & infections 2018-03, Vol.7 (1), p.1-9
Main Authors: Zhu, Houshun, Lee, Andrew C. Y., Li, Can, Mak, Winger W. N., Chen, Yetta Y., Chan, Kwok-Hung, Zhang, Anna J. X., Fung, Wai-Fong, Zhang, Rui-Qi, Fung, Yim-Fong, Poon, Rosana W. S., Lam, Joy-Yan, Tam, Sidney, Hung, Ivan F. N., Chen, Honglin, Yuen, Kwok-Yung, To, Kelvin K. W.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antibodies
Antibodies, Neutralizing - blood
Antibodies, Viral - blood
Cell culture
Female
Hong Kong - epidemiology
Humans
Immunization
Influenza
Influenza A Virus, H3N2 Subtype - classification
Influenza A Virus, H3N2 Subtype - genetics
Influenza A Virus, H3N2 Subtype - immunology
Influenza A Virus, H3N2 Subtype - isolation & purification
Influenza Vaccines - administration & dosage
Influenza Vaccines - immunology
Influenza, Human - blood
Influenza, Human - epidemiology
Influenza, Human - virology
Male
Middle Aged
Phylogeny
Seasons
Vaccination
Vaccines
Viruses
Young Adult
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Summary:The 2017 Hong Kong influenza A(H3N2) summer season was unexpectedly severe. However, antigenic characterization of the 2017 circulating A(H3N2) viruses using ferret antisera did not show significant antigenic drift. We analyzed the hemagglutinin amino acid sequences of A(H3N2) virus circulating in Hong Kong in 2017, and found that viruses with hemagglutinin N121K substitution, which was rare before 2017, emerged rapidly and dominated in 2017 (52.4% of A[H3N2] virus in 2017 contains N121K substitution). Microneutralization assay using archived human sera collected from mid-2017 showed that the geometric mean microneutralization titer was 3.6-fold lower against a 2017 cell culture-grown circulating A(H3N2)-N121K virus (3391/2017 virus) than that against the cell culture-grown 2016-2017 A(H3N2) seasonal influenza vaccine-like vaccine virus (4801/2014 virus) (13.4 vs 41.8, P 
ISSN:2222-1751
2222-1751
DOI:10.1038/s41426-018-0041-1