Lopinavir ritonavir Reduces Bupropion Plasma Concentrations in Healthy Subjects

Limited data are available about the effect of steady‐state lopinavir and ritonavir (LPV/r) on bupropion pharmacokinetics. As patients may benefit by using these two agents in combination, this study determined the extent and direction of this drug–drug interaction. Twelve healthy volunteers receive...

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Bibliographic Details
Published in:Clinical pharmacology and therapeutics 2007-01, Vol.81 (1), p.69-75
Main Authors: Hogeland, G W, Swindells, S, McNabb, J C, Kashuba, A D M, Yee, G C, Lindley, C M
Format: Article
Language:English
Subjects:
Adult
Antidepressive Agents, Second-Generation - blood
Antidepressive Agents, Second-Generation - pharmacokinetics
Area Under Curve
Biological and medical sciences
Bupropion - analogs & derivatives
Bupropion - blood
Bupropion - pharmacokinetics
Drug Antagonism
Drug Combinations
Female
Half-Life
HIV Protease Inhibitors - administration & dosage
HIV Protease Inhibitors - pharmacology
Humans
Lopinavir
Male
Medical sciences
Metabolic Clearance Rate
Pharmacology. Drug treatments
Pyrimidinones - administration & dosage
Pyrimidinones - pharmacology
Ritonavir - administration & dosage
Ritonavir - pharmacology
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Summary:Limited data are available about the effect of steady‐state lopinavir and ritonavir (LPV/r) on bupropion pharmacokinetics. As patients may benefit by using these two agents in combination, this study determined the extent and direction of this drug–drug interaction. Twelve healthy volunteers received a single 100 mg dose of sustained‐release bupropion before and after 2 weeks of treatment with LPV/r 400 mg/100 mg twice daily. Pharmacokinetics profiles were determined on days 1 and 30 for bupropion and hydroxybupropion and days 29 and 30 for LPV/r. LPV/r administration significantly decreased bupropion maximum plasma concentration (Cmax) by 57% (90% confidence interval (CI), 38–76% P
ISSN:0009-9236
1532-6535
DOI:10.1038/sj.clpt.6100027