Aromatic chloride to nitrile transformation: medicinal and synthetic chemistry

This review highlights the medicinal and synthetic chemistry relevance of replacing an aromatic chloride motif with an aromatic nitrile. We explore the desirable features that this transformation can bring in a drug design sense and the recent synthetic chemistry advances that effect this replacemen...

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Bibliographic Details
Published in:MedChemComm 2010-12, Vol.1 (5), p.309-318
Main Authors: Jones, Lyn H., Summerhill, Nicholas W., Swain, Nigel A., Mills, James E.
Format: Article
Language:English
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Summary:This review highlights the medicinal and synthetic chemistry relevance of replacing an aromatic chloride motif with an aromatic nitrile. We explore the desirable features that this transformation can bring in a drug design sense and the recent synthetic chemistry advances that effect this replacement in a single step.
ISSN:2040-2503
2040-2511
DOI:10.1039/C0MD00135J