Active diffusion-limited aggregation of cells

Biological self-assembly is a useful tool to build living tissues for medical applications or in vitro studies. Here we investigate the ability of cells to self-organize and construct three-dimensional cellular structures on non-adhesive substrates. When cells are deposited on a PolyEthyleneGlycol-c...

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Published in:Soft matter 2012-01, Vol.8 (3), p.784-788
Main Authors: Douezan, Stphane, Brochard-Wyart, Franoise
Format: Article
Language:English
Subjects:
Agglomeration
Biological
Construction
Diffusion
Medical
Self assembly
Three dimensional
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description Biological self-assembly is a useful tool to build living tissues for medical applications or in vitro studies. Here we investigate the ability of cells to self-organize and construct three-dimensional cellular structures on non-adhesive substrates. When cells are deposited on a PolyEthyleneGlycol-coated substrate, they diffuse randomly and eventually meet to form clusters that consolidate into three-dimensional aggregates. We describe the observed dynamics of aggregation by accounting for cell motility and tissue compaction due to surface tension. The ability of cells to self-organize and construct three-dimensional cellular structures on non-adhesive substrates is investigated.
doi_str_mv 10.1039/c1sm06399e
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source Royal Society of Chemistry
subjects Agglomeration
Biological
Construction
Diffusion
Medical
Self assembly
Three dimensional
title Active diffusion-limited aggregation of cells
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