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Structures of benzoic acids with substituted pyridines and quinolines: salt versus co-crystal formation
A series of five substituted benzoic acids with 10 substituted pyridines and quinolines have been crystallized so that their Δp K a , defined as p K a base –p K a acid , varied from −1.14 to +4.16. This spans the ‘uncertainty’ region for the formation of salt versus co-crystals. Although most of our...
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| Published in: | CrystEngComm 2014-01, Vol.16 (26), p.5802-5810 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c304t-cded5a099efe828438d0ce5a95f1af50fdbb2fd6712858c0b4b7c00b9d3273733 |
| container_end_page | 5810 |
| container_issue | 26 |
| container_start_page | 5802 |
| container_title | CrystEngComm |
| container_volume | 16 |
| creator | Ramon, Gaëlle Davies, Kate Nassimbeni, Luigi R. |
| description | A series of five substituted benzoic acids with 10 substituted pyridines and quinolines have been crystallized so that their Δp
K
a
, defined as p
K
a base
–p
K
a acid
, varied from −1.14 to +4.16. This spans the ‘uncertainty’ region for the formation of salt
versus
co-crystals. Although most of our results confirmed that structure formation of co-crystal
versus
salt parts at Δp
K
a
≈ 2, we report here a structure that does not follow the general rule and serves as a cautionary tale. |
| doi_str_mv | 10.1039/C3CE41963K |
| format | article |
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K
a
, defined as p
K
a base
–p
K
a acid
, varied from −1.14 to +4.16. This spans the ‘uncertainty’ region for the formation of salt
versus
co-crystals. Although most of our results confirmed that structure formation of co-crystal
versus
salt parts at Δp
K
a
≈ 2, we report here a structure that does not follow the general rule and serves as a cautionary tale.</description><identifier>ISSN: 1466-8033</identifier><identifier>EISSN: 1466-8033</identifier><identifier>DOI: 10.1039/C3CE41963K</identifier><language>eng</language><ispartof>CrystEngComm, 2014-01, Vol.16 (26), p.5802-5810</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c304t-cded5a099efe828438d0ce5a95f1af50fdbb2fd6712858c0b4b7c00b9d3273733</citedby><cites>FETCH-LOGICAL-c304t-cded5a099efe828438d0ce5a95f1af50fdbb2fd6712858c0b4b7c00b9d3273733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Ramon, Gaëlle</creatorcontrib><creatorcontrib>Davies, Kate</creatorcontrib><creatorcontrib>Nassimbeni, Luigi R.</creatorcontrib><title>Structures of benzoic acids with substituted pyridines and quinolines: salt versus co-crystal formation</title><title>CrystEngComm</title><description>A series of five substituted benzoic acids with 10 substituted pyridines and quinolines have been crystallized so that their Δp
K
a
, defined as p
K
a base
–p
K
a acid
, varied from −1.14 to +4.16. This spans the ‘uncertainty’ region for the formation of salt
versus
co-crystals. Although most of our results confirmed that structure formation of co-crystal
versus
salt parts at Δp
K
a
≈ 2, we report here a structure that does not follow the general rule and serves as a cautionary tale.</description><issn>1466-8033</issn><issn>1466-8033</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNpNkM1KAzEYRYMoWKsbnyBrYfTLZP7iToZaxYILdT3kVyPTSc2XKPXptSjo6t4Lh7s4hJwyOGfAxUXP-0XFRMPv9siMVU1TdMD5_r9-SI4QXwFYxRjMyPNDilmnHC3S4Kiy02fwmkrtDdIPn14oZoXJp5ysoZtt9MZP36ycDH3Lfgrjbl5SlGOi7zZiRqpDoeMWkxypC3Etkw_TMTlwckR78ptz8nS9eOxvitX98ra_WhWaQ5UKbaypJQhhne3KruKdAW1rKWrHpKvBGaVKZ5qWlV3daVCVajWAEoaXLW85n5Ozn18dA2K0bthEv5ZxOzAYdoqGP0X8C__SXCM</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Ramon, Gaëlle</creator><creator>Davies, Kate</creator><creator>Nassimbeni, Luigi R.</creator><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20140101</creationdate><title>Structures of benzoic acids with substituted pyridines and quinolines: salt versus co-crystal formation</title><author>Ramon, Gaëlle ; Davies, Kate ; Nassimbeni, Luigi R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c304t-cded5a099efe828438d0ce5a95f1af50fdbb2fd6712858c0b4b7c00b9d3273733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramon, Gaëlle</creatorcontrib><creatorcontrib>Davies, Kate</creatorcontrib><creatorcontrib>Nassimbeni, Luigi R.</creatorcontrib><collection>CrossRef</collection><jtitle>CrystEngComm</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramon, Gaëlle</au><au>Davies, Kate</au><au>Nassimbeni, Luigi R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structures of benzoic acids with substituted pyridines and quinolines: salt versus co-crystal formation</atitle><jtitle>CrystEngComm</jtitle><date>2014-01-01</date><risdate>2014</risdate><volume>16</volume><issue>26</issue><spage>5802</spage><epage>5810</epage><pages>5802-5810</pages><issn>1466-8033</issn><eissn>1466-8033</eissn><abstract>A series of five substituted benzoic acids with 10 substituted pyridines and quinolines have been crystallized so that their Δp
K
a
, defined as p
K
a base
–p
K
a acid
, varied from −1.14 to +4.16. This spans the ‘uncertainty’ region for the formation of salt
versus
co-crystals. Although most of our results confirmed that structure formation of co-crystal
versus
salt parts at Δp
K
a
≈ 2, we report here a structure that does not follow the general rule and serves as a cautionary tale.</abstract><doi>10.1039/C3CE41963K</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1466-8033 |
| ispartof | CrystEngComm, 2014-01, Vol.16 (26), p.5802-5810 |
| issn | 1466-8033 1466-8033 |
| language | eng |
| recordid | cdi_crossref_primary_10_1039_C3CE41963K |
| source | Royal Society of Chemistry |
| title | Structures of benzoic acids with substituted pyridines and quinolines: salt versus co-crystal formation |
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