Direct functionalization of unactivated C-H bonds catalyzed by group 3-5 metal alkyl complexes

This perspective summarizes direct C-H bond functionalization reactions catalyzed by group 3-5 metal alkyl complexes. Metal-carbon bonds of group 3-5 metals have potentially high reactivity toward both C-H bond activation reactions through the intrinsic σ-bond metathesis pathway and insertion of uns...

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Bibliographic Details
Published in:Dalton transactions : an international journal of inorganic chemistry 2014-01, Vol.43 (6), p.2331-2343
Main Authors: Tsurugi, Hayato, Yamamoto, Koji, Nagae, Haruki, Kaneko, Hiroshi, Mashima, Kazushi
Format: Article
Language:English
Subjects:
Activation
Alkylamines
Catalysis
Catalysts
Ligands
Methane
Terminals
Transformations
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Summary:This perspective summarizes direct C-H bond functionalization reactions catalyzed by group 3-5 metal alkyl complexes. Metal-carbon bonds of group 3-5 metals have potentially high reactivity toward both C-H bond activation reactions through the intrinsic σ-bond metathesis pathway and insertion of unsaturated organic molecules. Upon the combination of these two elemental steps, direct C-H bond functionalization reactions of (hetero)aromatic compounds, methane, alkylamines, and terminal alkynes, proceed through C(sp)-H, C(sp 2 )-H, and C(sp 3 )-H bond activation reactions. Here we review as catalysts for these transformations not only simple metallocene complexes but also non-metallocene complexes supported by a variety of ligands, which are often superior in terms of catalyst design and catalytic activity. We reviewed recent achievements in catalytic C-C and C-Si bond forming reactions through C-H bond activation by group 3-5 metal complexes.
ISSN:1477-9226
1477-9234
DOI:10.1039/c3dt52758a