Chemoselective N-deacetylation under mild conditions

A mild and efficient chemoselective N-deacetylation using the Schwartz reagent at room temperature in rapid time is described. The mild and neutral conditions enable orthogonal N-deacetylation in the presence of some of the common protecting groups ( viz . Boc, Fmoc, Cbz, Ts). The deprotection condi...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2014-01, Vol.12 (2), p.261-264
Main Authors: Sultane, Prakash R, Mete, Trimbak B, Bhat, Ramakrishna G
Format: Article
Language:English
Subjects:
Acetamides - chemistry
Acetylation
Amines - chemical synthesis
Amines - chemistry
Molecular Structure
Temperature
Time Factors
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Summary:A mild and efficient chemoselective N-deacetylation using the Schwartz reagent at room temperature in rapid time is described. The mild and neutral conditions enable orthogonal N-deacetylation in the presence of some of the common protecting groups ( viz . Boc, Fmoc, Cbz, Ts). The deprotection conditions did not induce any epimerization at the chiral amino centre. A mild and efficient chemoselective N-deacetylation using the Schwartz reagent at room temperature in rapid time is described.
ISSN:1477-0520
1477-0539
DOI:10.1039/c3ob41971a