Striped, bioactive Ce-TiO 2 materials with peroxynitrite-scavenging activity

Controlling aligned fiber micro-architectures to simulate the extracellular matrix for inducing important biological functions is a key challenge with regard to successful tissue regeneration. Here we present a bottom-up microemulsion-mediated strategy to obtain highly bioactive and biocompatible, s...

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2014-02, Vol.2 (7), p.834-845
Main Authors: Gravina, A Noel, Ruso, Juan M, Laiuppa, Juan A, Santillán, Graciela E, Marco-Brown, Jose L, D'Elia, Noelia L, Messina, Paula V
Format: Article
Language:English
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Summary:Controlling aligned fiber micro-architectures to simulate the extracellular matrix for inducing important biological functions is a key challenge with regard to successful tissue regeneration. Here we present a bottom-up microemulsion-mediated strategy to obtain highly bioactive and biocompatible, striped Ce-TiO nano-crystalline superstructures with ONOO scavenging activity. The employment of a bulkier organic ceria precursor in the material synthesis has several concurrent effects: (I) influencing the interfacial microemulsion droplet elasticity to create an aligned distribution of prismatic anatase nanoparticles causing the final lined morphology, (II) stabilizing the anatase active phase in a fine dispersed state and improving its resistance to the thermal anatase-rutile conversion, (III) indirectly favoring the rapid formation on the material surface of a hydroxyapatite layer composed of sphere-like globules of 3-5 μm in diameter essential for bone-bonding, and finally (IV) accelerating the ONOO degradation into less harmful species NO and O .
ISSN:2050-750X
2050-7518
DOI:10.1039/C3TB21556C