A bioorthogonal 68 Ga-labelling strategy for rapid in vivo imaging

Herein, we describe a fast and robust method for achieving 68 Ga-labelling of the EGFR-selective monoclonal antibody (mAb) Cetuximab using the bioorthogonal Inverse-electron-Demand Diels–Alder (IeDDA) reaction. The in vivo imaging of EGFR is demonstrated, as well as the translation of the method wit...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2014, Vol.50 (67), p.9557-9560
Main Authors: Evans, Helen L., Nguyen, Quang-Dé, Carroll, Laurence S., Kaliszczak, Maciej, Twyman, Frazer J., Spivey, Alan C., Aboagye, Eric O.
Format: Article
Language:English
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Summary:Herein, we describe a fast and robust method for achieving 68 Ga-labelling of the EGFR-selective monoclonal antibody (mAb) Cetuximab using the bioorthogonal Inverse-electron-Demand Diels–Alder (IeDDA) reaction. The in vivo imaging of EGFR is demonstrated, as well as the translation of the method within a two-step pretargeting strategy.
ISSN:1359-7345
1364-548X
DOI:10.1039/C4CC03903C