Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences

Biophysical studies of ligand interactions with three human telomeric repeat sequences (d(AGGG(TTAGGG) n , n = 3, 7 and 11)) show that an oxazole-based 'click' ligand, which induces parallel folded quadruplexes, preferentially stabilises longer telomeric repeats providing evidence for sele...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2014-12, Vol.5 (96), p.1522-1525
Main Authors: Cousins, Alex R. O, Ritson, Dougal, Sharma, Pallavi, Stevens, Malcolm F. G, Moses, John E, Searle, Mark S
Format: Article
Language:English
Subjects:
Base Sequence
Binding
Binding Sites
Circular Dichroism
Click Chemistry
Deoxyribonucleic acid
G-Quadruplexes
Gene sequencing
Humans
Ligands
Molecular Dynamics Simulation
Nucleic Acid Conformation
Oxazoles - chemistry
Selectivity
Telomere - chemistry
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Summary:Biophysical studies of ligand interactions with three human telomeric repeat sequences (d(AGGG(TTAGGG) n , n = 3, 7 and 11)) show that an oxazole-based 'click' ligand, which induces parallel folded quadruplexes, preferentially stabilises longer telomeric repeats providing evidence for selectivity in binding at the interface between tandem quadruplex motifs. An oxazole-based 'click' ligand shows selectivity in binding at the interface between tandem telomeric DNA quadruplex motifs.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc07487d