Evaluation of multi-collector inductively coupled plasma mass spectrometry (MC-ICP-MS) for sulfur metabolic studies using 34 S-labelled yeast

A multi-collector ICP-MS instrument was evaluated for the on-line measurement of sulfur isotope ratios during the liquid chromatographic separation of sulfur metabolites in mouse urine after the oral administration of 34 S-labelled yeast. The multi-collector instrument used was equipped with both Fa...

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Bibliographic Details
Published in:Journal of analytical atomic spectrometry 2015, Vol.30 (8), p.1764-1773
Main Authors: San Blas, Oscar Galilea, Marchante Gayón, Juan Manuel, García Alonso, José Ignacio
Format: Article
Language:English
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Summary:A multi-collector ICP-MS instrument was evaluated for the on-line measurement of sulfur isotope ratios during the liquid chromatographic separation of sulfur metabolites in mouse urine after the oral administration of 34 S-labelled yeast. The multi-collector instrument used was equipped with both Faraday cups and ion counters at positions L4 (32), C (33) and H4 (34). For the optimisation of the resolution, cup configuration and measurement conditions an artificial mixture of natural sulfur and highly enriched 33 S and 34 S was prepared. The results were compared with those obtained using a sector field single collector instrument from the same manufacturer. Both instruments provided good accuracy in the measurement of sulfur isotope ratios but better precision (
ISSN:0267-9477
1364-5544
DOI:10.1039/C4JA00383G