cis-2-Aminocyclohex-4-enecarboxylic acid as a new building block of helical foldamers

cis -2-Aminocyclohex-4-enecarboxylic acid ( cis -ACHE) is a conformationally constrained β-amino acid. We showed that the conformational preference of a cis -ACHE residue is similar to that of cis -2-aminocyclohexanecarboxylic acid. α/β-Peptides that consist of the alternation of (1 S ,2 R )- cis -A...

Full description

Saved in:
Bibliographic Details
Published in:New journal of chemistry 2015-01, Vol.39 (5), p.3221-3224
Main Authors: Kwon, Sunmi, Kang, Philjae, Choi, Moon-Gun, Choi, Soo Hyuk
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:cis -2-Aminocyclohex-4-enecarboxylic acid ( cis -ACHE) is a conformationally constrained β-amino acid. We showed that the conformational preference of a cis -ACHE residue is similar to that of cis -2-aminocyclohexanecarboxylic acid. α/β-Peptides that consist of the alternation of (1 S ,2 R )- cis -ACHE and l -alanine adopted 11/9-helical conformations in solution and in the crystal state.
ISSN:1144-0546
1369-9261
DOI:10.1039/C4NJ02056A