Greener [3+3] tandem annulation–oxidation approach towards the synthesis of substituted pyrimidines

An economical and green synthesis of partly and fully substituted pyrimidines is described using α,β-unsaturated ketones and benzamidine hydrochloride using greener and recyclable choline hydroxide (ChOH) as both a catalyst and a reaction medium. The remarkable features of this method are mild react...

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Bibliographic Details
Published in:New journal of chemistry 2015-01, Vol.39 (5), p.3639-3645
Main Authors: Vadagaonkar, Kamlesh S., Kalmode, Hanuman P., Prakash, Sattey, Chaskar, Atul C.
Format: Article
Language:English
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Summary:An economical and green synthesis of partly and fully substituted pyrimidines is described using α,β-unsaturated ketones and benzamidine hydrochloride using greener and recyclable choline hydroxide (ChOH) as both a catalyst and a reaction medium. The remarkable features of this method are mild reaction conditions, short reaction times, easy workup procedure, recyclability of the catalyst and excellent yields of the products. The reaction involves a [3+3] annulation–oxidation sequence and the protocol is useful for synthesizing a broad range of biologically significant pyrimidine derivatives.
ISSN:1144-0546
1369-9261
DOI:10.1039/C4NJ02345E