Engineered nanoparticles: thrombotic events in cancer

Engineered nanoparticles are being increasingly produced for specific applications in medicine. Broad selections of nano-sized constructs have been developed for applications in diagnosis, imaging, and drug delivery. Nanoparticles as contrast agents enable conjugation with molecular markers which ar...

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Bibliographic Details
Published in:Nanoscale 2014-11, Vol.6 (23), p.14141-14152
Main Authors: Abdalla, Ahmed M. E, Xiao, Lin, Ouyang, Chenxi, Yang, Guang
Format: Article
Language:English
Subjects:
Contrast Media - adverse effects
Contrast Media - chemistry
Contrast Media - therapeutic use
Humans
Nanoparticles - adverse effects
Nanoparticles - chemistry
Neoplasms - diagnosis
Thrombosis - diagnosis
Thrombosis - etiology
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Summary:Engineered nanoparticles are being increasingly produced for specific applications in medicine. Broad selections of nano-sized constructs have been developed for applications in diagnosis, imaging, and drug delivery. Nanoparticles as contrast agents enable conjugation with molecular markers which are essential for designing effective diagnostic and therapeutic strategies. Such investigations can also lead to a better understanding of disease mechanisms such as cancer-associated thrombosis which remains unpredictable with serious bleeding complications and high risk of death. Here we review the recent and current applications of engineered nanoparticles in diagnosis and therapeutic strategies, noting their toxicity in relation to specific markers as a target. Engineered nanoparticles are being increasingly produced for specific applications in medicine.
ISSN:2040-3364
2040-3372
DOI:10.1039/c4nr04825c