Facile cyclization in the synthesis of highly fused diaza cyclooctanoid compounds using retrievable nano magnetite-supported sulfonic acid catalyst

Magnetically separable Fe 3 O 4 –SO 3 H nano particles have been prepared and established as an efficient catalyst for the synthesis of dihydrofuran fused cyclooctanoids via the dehydration reaction of dihydroxy cyclooctanoid heterocylces. Nanomagnetite, Fe 3 O 4 –SO 3 H was prepared using an impreg...

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Bibliographic Details
Published in:RSC advances 2014, Vol.4 (45), p.23779-23789
Main Authors: Pathak, Sudipta, Debnath, Kamalesh, Mollick, Md. Masud Rahaman, Pramanik, Animesh
Format: Article
Language:English
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Summary:Magnetically separable Fe 3 O 4 –SO 3 H nano particles have been prepared and established as an efficient catalyst for the synthesis of dihydrofuran fused cyclooctanoids via the dehydration reaction of dihydroxy cyclooctanoid heterocylces. Nanomagnetite, Fe 3 O 4 –SO 3 H was prepared using an impregnation protocol and fully characterized by XRD, FT-IR, TEM, and FE-SEM-EDS. The catalyst was recycled for five consecutive cycles with almost unaltered catalytic activity. The dehydration step was performed keeping the acid sensitive amide linkage intact under ambient temperature and milder reaction conditions. The efficacy of the methodology lies in the excellent yield of product formation within a short span of reaction time avoiding undesirable side products due to the substrate decomposition by ring rupture and tedious purification and work-up procedure.
ISSN:2046-2069
2046-2069
DOI:10.1039/C4RA03384A