“On-water” synthesis of novel trisubstituted 1,3-thiazoles via microwave-assisted catalyst-free domino reactions

A clean, efficient and catalyst-free multicomponent domino reaction of arylglyoxals, cyclic 1,3-dicarbonyls and thioamides in aqueous media under microwave conditions is reported. A wide variety of trisubstituted thiazoles can be synthesized in good to very good yields using this green protocol. The...

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Bibliographic Details
Published in:RSC advances 2014, Vol.4 (71), p.37889-37899
Main Authors: Karamthulla, Shaik, Pal, Suman, Khan, Md. Nasim, Choudhury, Lokman H.
Format: Article
Language:English
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Summary:A clean, efficient and catalyst-free multicomponent domino reaction of arylglyoxals, cyclic 1,3-dicarbonyls and thioamides in aqueous media under microwave conditions is reported. A wide variety of trisubstituted thiazoles can be synthesized in good to very good yields using this green protocol. The salient features of this methodology are: catalyst-free reaction, water as reaction medium, short reaction time, good yields, use of microwave heating, and no harmful by-products.
ISSN:2046-2069
2046-2069
DOI:10.1039/C4RA06239F