One-pot solvent-free reductive amination with a solid ammonium carbamate salt from CO 2 and amine

Many amines are liquid and their handling is inconvenient compared with the corresponding solids. We transformed a liquid ( S )-(−)-1-phenylethylamine 1 to the corresponding neutral solid form 2 by reacting with carbon dioxide. We performed reductive amination of 2 with various aldehydes 3 under sol...

Full description

Saved in:
Bibliographic Details
Published in:RSC advances 2014, Vol.4 (86), p.46203-46207
Main Authors: Kang, Philjun, Lee, Kyu Myung, Lee, Won Koo, Lee, Kyu Hyung, Lee, Byeongno, Cho, Jaeheung, Hur, Nam Hwi
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Many amines are liquid and their handling is inconvenient compared with the corresponding solids. We transformed a liquid ( S )-(−)-1-phenylethylamine 1 to the corresponding neutral solid form 2 by reacting with carbon dioxide. We performed reductive amination of 2 with various aldehydes 3 under solvent-free conditions to provide secondary amines 5 in high yields.
ISSN:2046-2069
2046-2069
DOI:10.1039/C4RA07558G