Antineoplastic agents 596. Isolation and structure of chromomycin A 5 from a Beaufort Sea microorganism

A microorganism identified as Streptomyces sp. was isolated from a sedimentary specimen collected on the Beaufort Sea coast of Alaska. Fermentation scale-up and cancer cell line-guided separation of the constituents led to isolation and structural elucidation (high resolution MALDI-TOF mass and 2D N...

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Bibliographic Details
Published in:RSC advances 2015, Vol.5 (12), p.9116-9122
Main Authors: Pettit, George R., Tan, Rui, Pettit, Robin K., Doubek, Dennis L., Chapuis, Jean-Charles, Weber, Christine A.
Format: Article
Language:English
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Summary:A microorganism identified as Streptomyces sp. was isolated from a sedimentary specimen collected on the Beaufort Sea coast of Alaska. Fermentation scale-up and cancer cell line-guided separation of the constituents led to isolation and structural elucidation (high resolution MALDI-TOF mass and 2D NMR spectral analyses) of a diastereomer of chromomycin A2 ( 2 ) designated chromomycin A 5 ( 5 ). Chromomycin A 5 displayed very potent cancer cell growth inhibitory activity (reaching with MCF-7 breast cancer GI 50 0.00073 μg mL −1 ) against a mini-panel of murine and human cancer cell lines.
ISSN:2046-2069
2046-2069
DOI:10.1039/C4RA16517A