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Antineoplastic agents 596. Isolation and structure of chromomycin A 5 from a Beaufort Sea microorganism
A microorganism identified as Streptomyces sp. was isolated from a sedimentary specimen collected on the Beaufort Sea coast of Alaska. Fermentation scale-up and cancer cell line-guided separation of the constituents led to isolation and structural elucidation (high resolution MALDI-TOF mass and 2D N...
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| Published in: | RSC advances 2015, Vol.5 (12), p.9116-9122 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c76A-a26023b3c4c887e5c0a8e2f04395208056627d27318c068dd2d59e1fc337b2413 |
| container_end_page | 9122 |
| container_issue | 12 |
| container_start_page | 9116 |
| container_title | RSC advances |
| container_volume | 5 |
| creator | Pettit, George R. Tan, Rui Pettit, Robin K. Doubek, Dennis L. Chapuis, Jean-Charles Weber, Christine A. |
| description | A microorganism identified as
Streptomyces
sp. was isolated from a sedimentary specimen collected on the Beaufort Sea coast of Alaska. Fermentation scale-up and cancer cell line-guided separation of the constituents led to isolation and structural elucidation (high resolution MALDI-TOF mass and 2D NMR spectral analyses) of a diastereomer of chromomycin A2 (
2
) designated chromomycin A
5
(
5
). Chromomycin A
5
displayed very potent cancer cell growth inhibitory activity (reaching with MCF-7 breast cancer GI
50
0.00073 μg mL
−1
) against a mini-panel of murine and human cancer cell lines. |
| doi_str_mv | 10.1039/C4RA16517A |
| format | article |
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Streptomyces
sp. was isolated from a sedimentary specimen collected on the Beaufort Sea coast of Alaska. Fermentation scale-up and cancer cell line-guided separation of the constituents led to isolation and structural elucidation (high resolution MALDI-TOF mass and 2D NMR spectral analyses) of a diastereomer of chromomycin A2 (
2
) designated chromomycin A
5
(
5
). Chromomycin A
5
displayed very potent cancer cell growth inhibitory activity (reaching with MCF-7 breast cancer GI
50
0.00073 μg mL
−1
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Streptomyces
sp. was isolated from a sedimentary specimen collected on the Beaufort Sea coast of Alaska. Fermentation scale-up and cancer cell line-guided separation of the constituents led to isolation and structural elucidation (high resolution MALDI-TOF mass and 2D NMR spectral analyses) of a diastereomer of chromomycin A2 (
2
) designated chromomycin A
5
(
5
). Chromomycin A
5
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50
0.00073 μg mL
−1
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Streptomyces
sp. was isolated from a sedimentary specimen collected on the Beaufort Sea coast of Alaska. Fermentation scale-up and cancer cell line-guided separation of the constituents led to isolation and structural elucidation (high resolution MALDI-TOF mass and 2D NMR spectral analyses) of a diastereomer of chromomycin A2 (
2
) designated chromomycin A
5
(
5
). Chromomycin A
5
displayed very potent cancer cell growth inhibitory activity (reaching with MCF-7 breast cancer GI
50
0.00073 μg mL
−1
) against a mini-panel of murine and human cancer cell lines.</abstract><doi>10.1039/C4RA16517A</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 2046-2069 |
| ispartof | RSC advances, 2015, Vol.5 (12), p.9116-9122 |
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| language | eng |
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| source | Royal Society of Chemistry |
| title | Antineoplastic agents 596. Isolation and structure of chromomycin A 5 from a Beaufort Sea microorganism |
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