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The base-promoted synthesis of multisubstituted benzo[][1,4]oxazepines
A novel protocol to synthesize multisubstituted benzo[ b ][1,4]oxazepines from N -(2-haloaryl)enaminones has been developed. In this procedure, only 2 equiv. of Cs 2 CO 3 was required. A variety of polysubstituted benzo[ b ][1,4]oxazepine derivatives were provided in up to 95% yield for 27 examples....
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Published in: | Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (16), p.3292-3295 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | A novel protocol to synthesize multisubstituted benzo[
b
][1,4]oxazepines from
N
-(2-haloaryl)enaminones has been developed. In this procedure, only 2 equiv. of Cs
2
CO
3
was required. A variety of polysubstituted benzo[
b
][1,4]oxazepine derivatives were provided in up to 95% yield for 27 examples.
A variety of substituted benzo[
b
][1,4]oxazepines have been prepared
via
base-promoted intramolecular
O
-arylation from
N
-(2-haloaryl)enaminones under metal-free conditions. |
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ISSN: | 1359-7345 1364-548X |
DOI: | 10.1039/c5cc09877g |