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The base-promoted synthesis of multisubstituted benzo[][1,4]oxazepines

A novel protocol to synthesize multisubstituted benzo[ b ][1,4]oxazepines from N -(2-haloaryl)enaminones has been developed. In this procedure, only 2 equiv. of Cs 2 CO 3 was required. A variety of polysubstituted benzo[ b ][1,4]oxazepine derivatives were provided in up to 95% yield for 27 examples....

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (16), p.3292-3295
Main Authors: Shen, Jinhai, Xue, Lulu, Lin, Xing, Cheng, Guolin, Cui, Xiuling
Format: Article
Language:English
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Summary:A novel protocol to synthesize multisubstituted benzo[ b ][1,4]oxazepines from N -(2-haloaryl)enaminones has been developed. In this procedure, only 2 equiv. of Cs 2 CO 3 was required. A variety of polysubstituted benzo[ b ][1,4]oxazepine derivatives were provided in up to 95% yield for 27 examples. A variety of substituted benzo[ b ][1,4]oxazepines have been prepared via base-promoted intramolecular O -arylation from N -(2-haloaryl)enaminones under metal-free conditions.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc09877g