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Radical-based regioselective cross-coupling of indoles and cycloalkanes

An investigation into the regiochemistry of radical functionalization of indoles using cycloalkanes through di- tert -butyl peroxide (DTBP)-promoted C(sp 3 )-H activation was conducted. A wide range of indoles bearing substituents at different positions was functionalized directly with simple cycloa...

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Bibliographic Details
Published in:Catalysis science & technology 2016-01, Vol.6 (4), p.998-12
Main Authors: Xiu, Jianmin, Yi, Wenbin
Format: Article
Language:English
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Summary:An investigation into the regiochemistry of radical functionalization of indoles using cycloalkanes through di- tert -butyl peroxide (DTBP)-promoted C(sp 3 )-H activation was conducted. A wide range of indoles bearing substituents at different positions was functionalized directly with simple cycloalkanes in moderate to high regioselectivity. 2-, 4- and 7-positions were mainly functionalized. An investigation on regiochemistry of radical functionalization of indoles using cycloalkanes through di- tert -butyl peroxide (DTBP)-promoted C(sp 3 )-H activation was conducted. A wide range of indoles bearing substituents at different position was functionalized directly with simple cycloalkanes in moderate to high regioselctivity.
ISSN:2044-4753
2044-4761
DOI:10.1039/c5cy01907a