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Radical-based regioselective cross-coupling of indoles and cycloalkanes
An investigation into the regiochemistry of radical functionalization of indoles using cycloalkanes through di- tert -butyl peroxide (DTBP)-promoted C(sp 3 )-H activation was conducted. A wide range of indoles bearing substituents at different positions was functionalized directly with simple cycloa...
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Published in: | Catalysis science & technology 2016-01, Vol.6 (4), p.998-12 |
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Main Authors: | , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | An investigation into the regiochemistry of radical functionalization of indoles using cycloalkanes through di-
tert
-butyl peroxide (DTBP)-promoted C(sp
3
)-H activation was conducted. A wide range of indoles bearing substituents at different positions was functionalized directly with simple cycloalkanes in moderate to high regioselectivity. 2-, 4- and 7-positions were mainly functionalized.
An investigation on regiochemistry of radical functionalization of indoles using cycloalkanes through di-
tert
-butyl peroxide (DTBP)-promoted C(sp
3
)-H activation was conducted. A wide range of indoles bearing substituents at different position was functionalized directly with simple cycloalkanes in moderate to high regioselctivity. |
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ISSN: | 2044-4753 2044-4761 |
DOI: | 10.1039/c5cy01907a |