Effects of anthocyanins from purple sweet potato (Ipomoea batatas L. cultivar Eshu No. 8) on the serum uric acid level and xanthine oxidase activity in hyperuricemic mice

• Published in: Food & function 2015-09, Vol.6 (9), p.345-355
• Main Authors: Zhang, Zi-Cheng, Su, Guan-Hua, Luo, Chun-Li, Pang, Ya-Lu, Wang, Lin, Li, Xing, Wen, Jia-Hao, Zhang, Jiu-Liang
• Format: Article
• Language: English
• Subjects: Animals; Anthocyanins - administration & dosage; Anthocyanins - chemistry; Glucose Transport Proteins, Facilitative - genetics; Glucose Transport Proteins, Facilitative - metabolism; Humans; Hyperuricemia - blood; Hyperuricemia - drug therapy; Ipomoea; Ipomoea batatas - chemistry; Kidney - drug effects; Kidney - metabolism; Male; Mice; Organic Anion Transport Protein 1 - genetics; Organic Anion Transport Protein 1 - metabolism; Organic Anion Transporters - genetics; Organic Anion Transporters - metabolism; Plant Extracts - administration & dosage; Plant Extracts - chemistry; Solanum tuberosum; Uric Acid - blood; Xanthine Oxidase - blood; Xanthine Oxidase - genetics
• ISSN: 2042-6496; 2042-650X
• DOI: 10.1039/c5fo00499c

This study was aimed at evaluating the hypouricemic effect of the anthocyanin-rich purple sweet potato extract (APSPE). In vitro , APSPE has been proved to significantly inhibit XO activity in a dose-dependent manner. In vivo , APSPE could not only inhibit the XO activity in mouse liver, but also reduce the serum uric acid level in hyperuricemic mice and affect the expression of mRNA levels of related renal transporters, such as mURAT1, mGLUT9, mOAT1 and mOCTN2. Moreover, APSPE could effectively regulate BUN and Cr levels to normal and decrease the inflammatory cellular influx in the tubule of the hyperuricemic mice. This study indicates the potential clinical utility of APSPE as a safe and effective anti-hyperuricemia bioactive agent or functional food. This study was aimed at evaluating the hypouricemic effect of the anthocyanin-rich purple sweet potato extract (APSPE).