Filter-less submicron hydrodynamic size sorting

We propose a simple microfluidic device able to separate submicron particles (critical size ∼0.1 μm) from a complex sample with no filter (minimum channel dimension being 5 μm) by hydrodynamic filtration. A model taking into account the actual velocity profile and hydrodynamic resistances enables pr...

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Bibliographic Details
Published in:Lab on a chip 2016-01, Vol.16 (4), p.72-733
Main Authors: Fouet, M, Mader, M.-A, Iraïn, S, Yanha, Z, Naillon, A, Cargou, S, Gué, A.-M, Joseph, P
Format: Article
Language:English
Subjects:
Channels
Chips
Computational fluid dynamics
Engineering Sciences
Fluid flow
Fluid mechanics
Hydrodynamics
Mathematical models
Mechanics
Micro and nanotechnologies
Microelectronics
Physics
Sorting
Three dimensional
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Summary:We propose a simple microfluidic device able to separate submicron particles (critical size ∼0.1 μm) from a complex sample with no filter (minimum channel dimension being 5 μm) by hydrodynamic filtration. A model taking into account the actual velocity profile and hydrodynamic resistances enables prediction of the chip sorting properties for any geometry. Two design families are studied to obtain (i) small sizes within minutes (low-aspect ratio, two-level chip) and (ii) micron-sized sorting with a μL flow rate (3D architecture based on lamination). We obtain quantitative agreement of sorting performances both with experiments and with numerical solving, and determine the limits of the approach. We therefore demonstrate a passive, filter-less sub-micron size sorting with a simple, robust, and easy to fabricate design. We push the limits of hydrodynamic filtration by demonstrating filter-less sorting of submicron particles, in line with the model and simulations.
ISSN:1473-0197
1473-0189
DOI:10.1039/c5lc00941c