Pneumatically actuated microvalve circuits for programmable automation of chemical and biochemical analysis

Programmable microfluidic platforms (PMPs) are enabling significant advances in the utility of microfluidics for chemical and biochemical analysis. Traditional microfluidic devices are analogous to application-specific devices - a new device is needed to implement each new chemical or biochemical as...

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Bibliographic Details
Published in:Lab on a chip 2016-01, Vol.16 (5), p.812-819
Main Authors: Kim, Jungkyu, Stockton, Amanda M, Jensen, Erik C, Mathies, Richard A
Format: Article
Language:English
Subjects:
Assaying
Biochemistry
Biomarkers
Chemical analysis
Devices
Digital electronics
Genetics
Humans
Lab-On-A-Chip Devices
Microfluidic Analytical Techniques - instrumentation
Microfluidic Analytical Techniques - methods
Microfluidics
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Summary:Programmable microfluidic platforms (PMPs) are enabling significant advances in the utility of microfluidics for chemical and biochemical analysis. Traditional microfluidic devices are analogous to application-specific devices - a new device is needed to implement each new chemical or biochemical assay. PMPs are analogous to digital electronic processors - all that is needed to implement a new assay is a change in the order of operations conducted by the device. In this review, we introduce PMPs based on normally-closed microvalves. We discuss recent applications of PMPs in diverse fields including genetic analysis, antibody-based biomarker analysis, and chemical analysis in planetary exploration. Prospects, challenges, and future concepts for this emerging technology will also be presented. This article reviews programmable microfluidic platforms using pneumatically actuated microvalve array and their applications on biological and chemical analysis.
ISSN:1473-0197
1473-0189
DOI:10.1039/c5lc01397f